Gene description for Pgrmc1
Gene name progesterone receptor membrane component 1
Gene symbol Pgrmc1
Other names/aliases 25-Dx
25Dx
MPR
VEMA
Species Rattus norvegicus
 Database cross references - Pgrmc1
ExoCarta ExoCarta_291948
Vesiclepedia VP_291948
Entrez Gene 291948
UniProt P70580  
 Pgrmc1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pgrmc1
Molecular Function
    steroid binding GO:0005496 IEA
    heme binding GO:0020037 ISO
    heme binding GO:0020037 ISS
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    heme biosynthetic process GO:0006783 ISO
    heme biosynthetic process GO:0006783 ISS
    axon guidance GO:0007411 IEP
    memory GO:0007613 IGI
    associative learning GO:0008306 IGI
    modification of synaptic structure GO:0099563 IGI
    positive regulation of lipoprotein transport GO:0140077 ISO
    positive regulation of lipoprotein transport GO:0140077 ISS
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
    negative regulation of synapse organization GO:1905809 IGI
Subcellular Localization
    extracellular region GO:0005576 IEA
    mitochondrial outer membrane GO:0005741 IEA
    mitochondrial outer membrane GO:0005741 ISO
    mitochondrial outer membrane GO:0005741 ISS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    endomembrane system GO:0012505 IBA
    postsynaptic density GO:0014069 TAS
    membrane GO:0016020 IBA
    smooth endoplasmic reticulum membrane GO:0030868 IEA
    neuron projection GO:0043005 IDA
    neuronal cell body GO:0043025 IDA
    cell body GO:0044297 IDA
    synapse GO:0045202 IDA
 Experiment description of studies that identified Pgrmc1 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pgrmc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STXBP5L  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Pgrmc1 is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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