Gene description for Sh3glb1
Gene name SH3-domain GRB2-like endophilin B1
Gene symbol Sh3glb1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Sh3glb1
ExoCarta ExoCarta_292156
Entrez Gene 292156
UniProt Q6AYE2  
 Sh3glb1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Sh3glb1
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    fatty acid binding GO:0005504 ISO
    lysophosphatidic acid acyltransferase activity GO:0042171 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    regulation of cytokinesis GO:0032465 ISO
    positive regulation of protein oligomerization GO:0032461 ISO
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    mitochondrion organization GO:0007005 ISO
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISO
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 ISO
    positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 ISO
    phospholipid biosynthetic process GO:0008654 ISO
    positive regulation of membrane tubulation GO:1903527 ISO
    apoptotic process GO:0006915 IEA
    cellular response to amino acid starvation GO:0034198 ISO
    protein oligomerization GO:0051259 ISO
    autophagic cell death GO:0048102 ISO
    'de novo' posttranslational protein folding GO:0051084 ISO
    cellular response to glucose starvation GO:0042149 ISO
    protein localization to vacuolar membrane GO:1903778 ISO
    regulation of protein stability GO:0031647 ISO
    positive regulation of autophagosome assembly GO:2000786 ISO
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 ISO
    positive regulation of autophagy GO:0010508 ISO
    membrane fission GO:0090148 ISO
    phosphatidic acid biosynthetic process GO:0006654 ISO
    receptor catabolic process GO:0032801 ISO
Subcellular Localization
    mitochondrial outer membrane GO:0005741 IEA
    protein complex GO:0043234 ISO
    extracellular exosome GO:0070062 ISO
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 ISO
    autophagosome membrane GO:0000421 ISO
    midbody GO:0030496 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Sh3glb1 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sh3glb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sh3glb1 is involved
No pathways found





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