Gene description for Sh3glb1
Gene name SH3-domain GRB2-like endophilin B1
Gene symbol Sh3glb1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Sh3glb1
ExoCarta ExoCarta_292156
Vesiclepedia VP_292156
Entrez Gene 292156
UniProt Q6AYE2  
 Sh3glb1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Sh3glb1
Molecular Function
    fatty acid binding GO:0005504 ISO
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    lysophosphatidic acid acyltransferase activity GO:0042171 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    phosphatidylinositol 3-kinase activator activity GO:0141038 ISO
Biological Process
    phosphatidic acid biosynthetic process GO:0006654 ISO
    apoptotic process GO:0006915 IEA
    apoptotic process GO:0006915 ISO
    mitochondrion organization GO:0007005 ISO
    phospholipid biosynthetic process GO:0008654 ISO
    positive regulation of autophagy GO:0010508 ISO
    positive regulation of protein-containing complex assembly GO:0031334 IEA
    positive regulation of protein-containing complex assembly GO:0031334 ISO
    regulation of protein stability GO:0031647 ISO
    regulation of cytokinesis GO:0032465 IEA
    regulation of cytokinesis GO:0032465 ISO
    receptor catabolic process GO:0032801 IEA
    receptor catabolic process GO:0032801 ISO
    cellular response to amino acid starvation GO:0034198 IEA
    cellular response to amino acid starvation GO:0034198 ISO
    cellular response to glucose starvation GO:0042149 IEA
    cellular response to glucose starvation GO:0042149 ISO
    autophagic cell death GO:0048102 IEA
    autophagic cell death GO:0048102 ISO
    positive regulation of dendrite morphogenesis GO:0050775 IMP
    'de novo' post-translational protein folding GO:0051084 ISO
    positive regulation of neurotrophin TRK receptor signaling pathway GO:0051388 IMP
    membrane organization GO:0061024 IBA
    membrane fission GO:0090148 IEA
    membrane fission GO:0090148 ISO
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 ISO
    positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 ISO
    positive regulation of membrane tubulation GO:1903527 IEA
    positive regulation of membrane tubulation GO:1903527 ISO
    positive regulation of establishment of protein localization to mitochondrion GO:1903749 ISO
    protein localization to vacuolar membrane GO:1903778 IEA
    protein localization to vacuolar membrane GO:1903778 ISO
    positive regulation of dendrite extension GO:1903861 IMP
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    regulation of early endosome to late endosome transport GO:2000641 IMP
    positive regulation of autophagosome assembly GO:2000786 IEA
    positive regulation of autophagosome assembly GO:2000786 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    autophagosome membrane GO:0000421 IEA
    autophagosome membrane GO:0000421 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    mitochondrial outer membrane GO:0005741 IEA
    early endosome GO:0005769 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    synaptic vesicle GO:0008021 IDA
    membrane GO:0016020 IBA
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
    midbody GO:0030496 IEA
    midbody GO:0030496 ISO
    protein-containing complex GO:0032991 IEA
    protein-containing complex GO:0032991 ISO
    neuronal cell body GO:0043025 IDA
    synapse GO:0045202 IEA
 Experiment description of studies that identified Sh3glb1 in sEVs
1
Experiment ID 90
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70|HSP90|TSG101|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sh3glb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STXBP5L  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Sh3glb1 is involved
No pathways found





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