Gene description for Arg1
Gene name arginase 1
Gene symbol Arg1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Arg1
ExoCarta ExoCarta_29221
Entrez Gene 29221
UniProt P07824  
 Arg1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Arg1
Molecular Function
    arginase activity GO:0004053 ISO
    manganese ion binding GO:0030145 IDA
Biological Process
    response to herbicide GO:0009635 IEP
    response to peptide hormone GO:0043434 IEP
    protein homotrimerization GO:0070207 IDA
    response to cadmium ion GO:0046686 IEP
    response to amine GO:0014075 IEP
    cellular response to interleukin-4 GO:0071353 IEP
    cellular response to hydrogen peroxide GO:0070301 IEP
    response to drug GO:0042493 IEP
    response to selenium ion GO:0010269 IEP
    response to steroid hormone GO:0048545 IEP
    response to amino acid GO:0043200 IEP
    cellular response to dexamethasone stimulus GO:0071549 IEP
    urea cycle GO:0000050 IEA
    cellular response to lipopolysaccharide GO:0071222 IEP
    female pregnancy GO:0007565 IEP
    regulation of L-arginine import GO:0010963 IDA
    lung development GO:0030324 IEP
    aging GO:0007568 IEP
    response to lipopolysaccharide GO:0032496 IEP
    response to zinc ion GO:0010043 IEP
    maternal process involved in female pregnancy GO:0060135 IEP
    response to vitamin E GO:0033197 IEP
    liver development GO:0001889 IEP
    arginine catabolic process to ornithine GO:0019547 IDA
    response to axon injury GO:0048678 IEP
    response to manganese ion GO:0010042 IEP
    mammary gland involution GO:0060056 IEP
    cellular response to transforming growth factor beta stimulus GO:0071560 IEP
    response to wounding GO:0009611 IEP
    response to vitamin A GO:0033189 IEP
    cellular response to glucagon stimulus GO:0071377 IEP
    arginine metabolic process GO:0006525 IDA
    response to methylmercury GO:0051597 IEP
    collagen biosynthetic process GO:0032964 IMP
    positive regulation of endothelial cell proliferation GO:0001938 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 ISO
    neuronal cell body GO:0043025 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IDA
    mitochondrial outer membrane GO:0005741 IDA
    neuron projection GO:0043005 IDA
 Experiment description of studies that identified Arg1 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Arg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Arg1 is involved
PathwayEvidenceSource
Urea cycle IEA Reactome





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