Gene description for Cbr1
Gene name carbonyl reductase 1
Gene symbol Cbr1
Other names/aliases Cbr
Species Rattus norvegicus
 Database cross references - Cbr1
ExoCarta ExoCarta_29224
Entrez Gene 29224
UniProt P47727  
 Cbr1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Cbr1
Molecular Function
    15-hydroxyprostaglandin dehydrogenase (NADP+) activity GO:0047021 IEA
    carbonyl reductase (NADPH) activity GO:0004090 ISS
    prostaglandin-E2 9-reductase activity GO:0050221 IEA
    oxidoreductase activity GO:0016491 IEA
Biological Process
    response to gonadotropin GO:0034698 IEP
    peptidyl-lysine modification GO:0018205 NAS
    response to lipopolysaccharide GO:0032496 IEP
    drug metabolic process GO:0017144 ISS
    oxidation-reduction process GO:0055114 IEA
    response to testosterone GO:0033574 IEP
    ovulation from ovarian follicle GO:0001542 IEP
    vitamin K metabolic process GO:0042373 ISS
    phylloquinone catabolic process GO:0042376 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 IDA
    microvillus GO:0005902 IDA
    cytosol GO:0005829 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified Cbr1 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cbr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cbr1 is involved
PathwayEvidenceSource
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) IEA Reactome





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