Gene description for Cbr1
Gene name carbonyl reductase 1
Gene symbol Cbr1
Other names/aliases Cbr
Species Rattus norvegicus
 Database cross references - Cbr1
ExoCarta ExoCarta_29224
Vesiclepedia VP_29224
Entrez Gene 29224
UniProt P47727  
 Cbr1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Cbr1
Molecular Function
    carbonyl reductase (NADPH) activity GO:0004090 IBA
    carbonyl reductase (NADPH) activity GO:0004090 IDA
    carbonyl reductase (NADPH) activity GO:0004090 IEA
    carbonyl reductase (NADPH) activity GO:0004090 ISO
    carbonyl reductase (NADPH) activity GO:0004090 ISS
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 ISO
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016655 ISO
    15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity GO:0047020 IEA
    15-hydroxyprostaglandin dehydrogenase (NADP+) activity GO:0047021 ISS
    prostaglandin E2 9-reductase activity GO:0050221 ISS
    S-nitrosoglutathione reductase (NADPH) activity GO:0160163 IEA
Biological Process
    ovulation from ovarian follicle GO:0001542 IEP
    lipid metabolic process GO:0006629 IEA
    steroid catabolic process GO:0006706 IDA
    xenobiotic metabolic process GO:0006805 ISO
    xenobiotic metabolic process GO:0006805 ISS
    glucocorticoid metabolic process GO:0008211 ISO
    epithelial cell differentiation GO:0030855 ISO
    response to estradiol GO:0032355 IDA
    response to lipopolysaccharide GO:0032496 IEP
    response to progesterone GO:0032570 IDA
    response to testosterone GO:0033574 IEP
    response to gonadotropin GO:0034698 IEP
    vitamin K metabolic process GO:0042373 ISO
    vitamin K metabolic process GO:0042373 ISS
    phylloquinone catabolic process GO:0042376 IDA
    prostaglandin catabolic process GO:1905344 IDA
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    microvillus GO:0005902 IDA
 Experiment description of studies that identified Cbr1 in sEVs
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cbr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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