Gene description for Itgb3
Gene name	integrin, beta 3
Gene symbol	Itgb3
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Itgb3
ExoCarta	ExoCarta_29302
Vesiclepedia	VP_29302
Entrez Gene	29302
Itgb3 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Itgb3

Molecular Function     fibronectin binding GO:0001968 IBA     fibronectin binding GO:0001968 IEA     fibronectin binding GO:0001968 ISO     protease binding GO:0002020 IEA     protease binding GO:0002020 ISO     protein disulfide isomerase activity GO:0003756 IEA     protein disulfide isomerase activity GO:0003756 ISO     protein kinase C binding GO:0005080 IEA     protein kinase C binding GO:0005080 ISO     integrin binding GO:0005178 IBA     integrin binding GO:0005178 IEA     integrin binding GO:0005178 ISO     protein binding GO:0005515 IPI     fibroblast growth factor binding GO:0017134 IEA     fibroblast growth factor binding GO:0017134 ISO     enzyme binding GO:0019899 ISO     C-X3-C chemokine binding GO:0019960 IEA     C-X3-C chemokine binding GO:0019960 ISO     insulin-like growth factor I binding GO:0031994 IEA     insulin-like growth factor I binding GO:0031994 ISO     neuregulin binding GO:0038132 IEA     neuregulin binding GO:0038132 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     vascular endothelial growth factor receptor 2 binding GO:0043184 IEA     vascular endothelial growth factor receptor 2 binding GO:0043184 ISO     metal ion binding GO:0046872 IEA     cell adhesion molecule binding GO:0050839 ISO     extracellular matrix binding GO:0050840 IEA     extracellular matrix binding GO:0050840 ISO     fibrinogen binding GO:0070051 IBA     fibrinogen binding GO:0070051 IDA Biological Process     positive regulation of endothelial cell proliferation GO:0001938 IEA     positive regulation of endothelial cell proliferation GO:0001938 ISO     positive regulation of cell-matrix adhesion GO:0001954 IEA     positive regulation of cell-matrix adhesion GO:0001954 ISO     positive regulation of leukocyte migration GO:0002687 IMP     cell-substrate junction assembly GO:0007044 IEA     cell-substrate junction assembly GO:0007044 ISO     cell adhesion GO:0007155 IEA     cell adhesion GO:0007155 TAS     cell-matrix adhesion GO:0007160 IBA     cell-matrix adhesion GO:0007160 IEA     cell-matrix adhesion GO:0007160 ISO     cell-matrix adhesion GO:0007160 ISO     integrin-mediated signaling pathway GO:0007229 IBA     integrin-mediated signaling pathway GO:0007229 IEA     embryo implantation GO:0007566 IEP     regulation of G protein-coupled receptor signaling pathway GO:0008277 IMP     positive regulation of endothelial cell migration GO:0010595 IEA     positive regulation of endothelial cell migration GO:0010595 ISO     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     negative regulation of macrophage derived foam cell differentiation GO:0010745 IEA     negative regulation of macrophage derived foam cell differentiation GO:0010745 ISO     positive regulation of fibroblast migration GO:0010763 IEA     positive regulation of fibroblast migration GO:0010763 IMP     positive regulation of fibroblast migration GO:0010763 ISO     negative regulation of lipid storage GO:0010888 IEA     negative regulation of lipid storage GO:0010888 ISO     response to activity GO:0014823 IEP     smooth muscle cell migration GO:0014909 IEA     smooth muscle cell migration GO:0014909 ISO     positive regulation of smooth muscle cell migration GO:0014911 IMP     cell migration GO:0016477 IBA     platelet activation GO:0030168 ISO     positive regulation of cell migration GO:0030335 ISO     cell-substrate adhesion GO:0031589 ISO     activation of protein kinase activity GO:0032147 ISO     negative regulation of lipid transport GO:0032369 IEA     negative regulation of lipid transport GO:0032369 ISO     regulation of protein localization GO:0032880 IEA     regulation of protein localization GO:0032880 ISO     regulation of protein localization GO:0032880 ISS     regulation of actin cytoskeleton organization GO:0032956 IEA     regulation of actin cytoskeleton organization GO:0032956 ISO     cell adhesion mediated by integrin GO:0033627 IBA     cell adhesion mediated by integrin GO:0033627 IEA     cell adhesion mediated by integrin GO:0033627 ISO     positive regulation of cell adhesion mediated by integrin GO:0033630 IMP     positive regulation of osteoblast proliferation GO:0033690 IEA     positive regulation of osteoblast proliferation GO:0033690 ISO     heterotypic cell-cell adhesion GO:0034113 IEA     heterotypic cell-cell adhesion GO:0034113 ISO     substrate adhesion-dependent cell spreading GO:0034446 IEA     substrate adhesion-dependent cell spreading GO:0034446 ISO     response to platelet-derived growth factor GO:0036119 IEP     cellular response to platelet-derived growth factor stimulus GO:0036120 IEA     cellular response to platelet-derived growth factor stimulus GO:0036120 ISO     apolipoprotein A-I-mediated signaling pathway GO:0038027 IEA     apolipoprotein A-I-mediated signaling pathway GO:0038027 ISO     apoptotic cell clearance GO:0043277 IEA     apoptotic cell clearance GO:0043277 ISO     positive regulation of angiogenesis GO:0045766 IMP     positive regulation of bone resorption GO:0045780 IMP     symbiont entry into host cell GO:0046718 IEA     platelet-derived growth factor receptor signaling pathway GO:0048008 IEA     platelet-derived growth factor receptor signaling pathway GO:0048008 ISO     positive regulation of fibroblast proliferation GO:0048146 IEA     positive regulation of fibroblast proliferation GO:0048146 ISO     mesodermal cell differentiation GO:0048333 IEA     mesodermal cell differentiation GO:0048333 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 IMP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     negative regulation of lipoprotein metabolic process GO:0050748 IEA     negative regulation of lipoprotein metabolic process GO:0050748 ISO     negative chemotaxis GO:0050919 IEA     negative chemotaxis GO:0050919 ISO     regulation of release of sequestered calcium ion into cytosol GO:0051279 IDA     regulation of serotonin uptake GO:0051611 IEA     regulation of serotonin uptake GO:0051611 ISO     regulation of serotonin uptake GO:0051611 ISS     regulation of protein tyrosine kinase activity GO:0061097 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     platelet aggregation GO:0070527 IBA     platelet aggregation GO:0070527 IEA     platelet aggregation GO:0070527 ISO     platelet aggregation GO:0070527 ISO     cellular response to mechanical stimulus GO:0071260 IEP     cellular response to xenobiotic stimulus GO:0071466 IEP     positive regulation of glomerular mesangial cell proliferation GO:0072126 IMP     blood coagulation, fibrin clot formation GO:0072378 IEA     blood coagulation, fibrin clot formation GO:0072378 ISO     maintenance of postsynaptic specialization structure GO:0098880 EXP     maintenance of postsynaptic specialization structure GO:0098880 IDA     regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IEA     regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 ISO     regulation of postsynaptic neurotransmitter receptor diffusion trapping GO:0150054 EXP     regulation of postsynaptic neurotransmitter receptor diffusion trapping GO:0150054 IDA     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IEA     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO     positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway GO:1900731 IMP     regulation of trophoblast cell migration GO:1901163 IEA     regulation of trophoblast cell migration GO:1901163 ISO     regulation of extracellular matrix organization GO:1903053 IEA     regulation of extracellular matrix organization GO:1903053 ISO     negative regulation of low-density lipoprotein receptor activity GO:1905598 ISO     cellular response to insulin-like growth factor stimulus GO:1990314 IEP     negative regulation of endothelial cell apoptotic process GO:2000352 IMP     positive regulation of T cell migration GO:2000406 IEA     positive regulation of T cell migration GO:2000406 ISO Subcellular Localization     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     cell-cell junction GO:0005911 IEA     cell-cell junction GO:0005911 ISO     focal adhesion GO:0005925 IBA     focal adhesion GO:0005925 IDA     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 ISO     integrin complex GO:0008305 IBA     integrin complex GO:0008305 IDA     integrin complex GO:0008305 ISO     external side of plasma membrane GO:0009897 IEA     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 IBA     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     lamellipodium membrane GO:0031258 IEA     lamellipodium membrane GO:0031258 ISO     filopodium membrane GO:0031527 IEA     filopodium membrane GO:0031527 ISO     microvillus membrane GO:0031528 IEA     microvillus membrane GO:0031528 ISO     ruffle membrane GO:0032587 IEA     ruffle membrane GO:0032587 ISO     protein-containing complex GO:0032991 ISO     integrin alphav-beta3 complex GO:0034683 IEA     integrin alphav-beta3 complex GO:0034683 ISO     alphav-beta3 integrin-PKCalpha complex GO:0035866 IEA     alphav-beta3 integrin-PKCalpha complex GO:0035866 ISO     alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 IEA     alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 ISO     alphav-beta3 integrin-HMGB1 complex GO:0035868 IEA     alphav-beta3 integrin-HMGB1 complex GO:0035868 ISO     melanosome GO:0042470 IEA     melanosome GO:0042470 ISO     receptor complex GO:0043235 ISO     synapse GO:0045202 IBA     synapse GO:0045202 ISO     synapse GO:0045202 ISS     postsynaptic membrane GO:0045211 IEA     integrin alphaIIb-beta3 complex GO:0070442 IEA     integrin alphaIIb-beta3 complex GO:0070442 ISO     alpha9-beta1 integrin-ADAM8 complex GO:0071133 IEA     alpha9-beta1 integrin-ADAM8 complex GO:0071133 ISO     synaptic membrane GO:0097060 IEA     synaptic membrane GO:0097060 ISO     glycinergic synapse GO:0098690 EXP     glycinergic synapse GO:0098690 IDA     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO