Gene description for Spcs2
Gene name signal peptidase complex subunit 2 homolog (S. cerevisiae)
Gene symbol Spcs2
Other names/aliases RGD1311253
Species Rattus norvegicus
 Database cross references - Spcs2
ExoCarta ExoCarta_293142
Vesiclepedia VP_293142
Entrez Gene 293142
 Spcs2 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Spcs2
Molecular Function
    peptidase activity GO:0008233 IEA
Biological Process
    signal peptide processing GO:0006465 IBA
    signal peptide processing GO:0006465 ISO
    protein targeting to ER GO:0045047 IBA
Subcellular Localization
    signal peptidase complex GO:0005787 IBA
    signal peptidase complex GO:0005787 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
 Experiment description of studies that identified Spcs2 in sEVs
1
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Spcs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STXBP5L  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Spcs2 is involved
No pathways found





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