Gene description for Ddt
Gene name D-dopachrome tautomerase
Gene symbol Ddt
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ddt
ExoCarta ExoCarta_29318
Vesiclepedia VP_29318
Entrez Gene 29318
UniProt P80254  
 Ddt identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Ddt
Molecular Function
    protease binding GO:0002020 ISO
    dopachrome isomerase activity GO:0004167 TAS
    cytokine receptor binding GO:0005126 ISO
    D-dopachrome decarboxylase activity GO:0033981 IDA
    D-dopachrome decarboxylase activity GO:0033981 ISO
    phenylpyruvate tautomerase activity GO:0050178 IBA
    phenylpyruvate tautomerase activity GO:0050178 ISO
Biological Process
    negative regulation of macrophage chemotaxis GO:0010760 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    melanin biosynthetic process GO:0042438 IEA
    positive regulation of inflammatory response GO:0050729 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified Ddt in exosomes
1
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ddt
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ddt is involved
No pathways found





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