Gene description for Slc6a18
Gene name solute carrier family 6 (neutral amino acid transporter), member 18
Gene symbol Slc6a18
Other names/aliases Rosit
Xtrp2
Species Rattus norvegicus
 Database cross references - Slc6a18
ExoCarta ExoCarta_29323
Vesiclepedia VP_29323
Entrez Gene 29323
UniProt Q62687  
 Slc6a18 identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc6a18
Molecular Function
    amino acid transmembrane transporter activity GO:0015171 ISO
    neutral L-amino acid transmembrane transporter activity GO:0015175 ISO
    symporter activity GO:0015293 IEA
    metal ion binding GO:0046872 IEA
    neutral L-amino acid:sodium:chloride symporter activity GO:0140931 IEA
    neutral L-amino acid:sodium:chloride symporter activity GO:0140931 ISO
    neutral L-amino acid:sodium:chloride symporter activity GO:0140931 ISS
Biological Process
    amino acid transmembrane transport GO:0003333 IEA
    amino acid transmembrane transport GO:0003333 ISO
    neurotransmitter transport GO:0006836 IEA
    amino acid transport GO:0006865 IBA
    amino acid transport GO:0006865 ISO
    hyperosmotic response GO:0006972 IEP
    hyperosmotic response GO:0006972 NAS
    neutral amino acid transport GO:0015804 IEA
    neutral amino acid transport GO:0015804 ISO
    neutral amino acid transport GO:0015804 ISS
    sodium ion transmembrane transport GO:0035725 IBA
    transmembrane transport GO:0055085 IEA
    renal amino acid absorption GO:1990297 IEA
    renal amino acid absorption GO:1990297 ISO
    renal amino acid absorption GO:1990297 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    brush border membrane GO:0031526 IEA
    brush border membrane GO:0031526 ISO
 Experiment description of studies that identified Slc6a18 in sEVs
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc6a18
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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