Gene description for Plcg2
Gene name	phospholipase C, gamma 2
Gene symbol	Plcg2
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Plcg2
ExoCarta	ExoCarta_29337
Vesiclepedia	VP_29337
Entrez Gene	29337
UniProt	P24135
Plcg2 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Plcg2

Molecular Function     phosphotyrosine residue binding GO:0001784 IEA     phosphotyrosine residue binding GO:0001784 ISO     phosphatidylinositol phospholipase C activity GO:0004435 IBA     phosphatidylinositol phospholipase C activity GO:0004435 IDA     phosphatidylinositol phospholipase C activity GO:0004435 IEA     phosphatidylinositol phospholipase C activity GO:0004435 ISO     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 ISO     scaffold protein binding GO:0097110 IEA     scaffold protein binding GO:0097110 ISO     phosphorylation-dependent protein binding GO:0140031 IEA     phosphorylation-dependent protein binding GO:0140031 ISO     protein tyrosine kinase binding GO:1990782 IEA     protein tyrosine kinase binding GO:1990782 ISO Biological Process     cell activation GO:0001775 ISO     response to yeast GO:0001878 IEA     response to yeast GO:0001878 ISO     positive regulation of receptor internalization GO:0002092 IEA     positive regulation of receptor internalization GO:0002092 ISO     stimulatory C-type lectin receptor signaling pathway GO:0002223 IEA     stimulatory C-type lectin receptor signaling pathway GO:0002223 ISO     toll-like receptor signaling pathway GO:0002224 IEA     toll-like receptor signaling pathway GO:0002224 ISO     macrophage activation involved in immune response GO:0002281 IEA     macrophage activation involved in immune response GO:0002281 ISO     follicular B cell differentiation GO:0002316 IEA     follicular B cell differentiation GO:0002316 ISO     positive regulation of dendritic cell cytokine production GO:0002732 IEA     positive regulation of dendritic cell cytokine production GO:0002732 ISO     phosphatidylinositol biosynthetic process GO:0006661 IEA     phosphatidylinositol biosynthetic process GO:0006661 ISO     phosphatidylinositol biosynthetic process GO:0006661 ISS     positive regulation of cytosolic calcium ion concentration GO:0007204 IMP     phospholipid catabolic process GO:0009395 IEA     regulation of gene expression GO:0010468 ISO     positive regulation of gene expression GO:0010628 IMP     positive regulation of gene expression GO:0010628 ISO     positive regulation of epithelial cell migration GO:0010634 IBA     programmed cell death GO:0012501 IEA     programmed cell death GO:0012501 ISO     regulation of lipid metabolic process GO:0019216 IEA     regulation of lipid metabolic process GO:0019216 ISO     calcium-mediated signaling GO:0019722 IEA     calcium-mediated signaling GO:0019722 ISO     B cell differentiation GO:0030183 ISO     lipopolysaccharide-mediated signaling pathway GO:0031663 IEA     lipopolysaccharide-mediated signaling pathway GO:0031663 ISO     response to magnesium ion GO:0032026 IDA     activation of store-operated calcium channel activity GO:0032237 ISO     positive regulation of type I interferon production GO:0032481 IEA     positive regulation of type I interferon production GO:0032481 ISO     response to lipopolysaccharide GO:0032496 ISO     positive regulation of interleukin-10 production GO:0032733 IEA     positive regulation of interleukin-10 production GO:0032733 ISO     positive regulation of interleukin-12 production GO:0032735 IEA     positive regulation of interleukin-12 production GO:0032735 ISO     positive regulation of interleukin-2 production GO:0032743 IEA     positive regulation of interleukin-2 production GO:0032743 ISO     positive regulation of interleukin-23 production GO:0032747 IEA     positive regulation of interleukin-23 production GO:0032747 ISO     positive regulation of interleukin-6 production GO:0032755 IEA     positive regulation of interleukin-6 production GO:0032755 ISO     positive regulation of tumor necrosis factor production GO:0032760 IEA     positive regulation of tumor necrosis factor production GO:0032760 ISO     inositol trisphosphate biosynthetic process GO:0032959 IEA     inositol trisphosphate biosynthetic process GO:0032959 ISO     response to ATP GO:0033198 IDA     intracellular signal transduction GO:0035556 IMP     intracellular signal transduction GO:0035556 ISO     B cell activation GO:0042113 ISO     negative regulation of programmed cell death GO:0043069 IEA     negative regulation of programmed cell death GO:0043069 ISO     regulation of canonical NF-kappaB signal transduction GO:0043122 IEA     regulation of canonical NF-kappaB signal transduction GO:0043122 ISO     positive regulation of MAPK cascade GO:0043410 IEA     positive regulation of MAPK cascade GO:0043410 ISO     phosphatidylinositol metabolic process GO:0046488 IBA     phosphatidylinositol-mediated signaling GO:0048015 IBA     response to axon injury GO:0048678 IEA     response to axon injury GO:0048678 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of calcium-mediated signaling GO:0050850 IEA     positive regulation of calcium-mediated signaling GO:0050850 ISO     T cell receptor signaling pathway GO:0050852 IEA     T cell receptor signaling pathway GO:0050852 ISO     B cell receptor signaling pathway GO:0050853 IEA     B cell receptor signaling pathway GO:0050853 ISO     positive regulation of DNA-binding transcription factor activity GO:0051091 IMP     positive regulation of DNA-binding transcription factor activity GO:0051091 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     release of sequestered calcium ion into cytosol GO:0051209 IBA     release of sequestered calcium ion into cytosol GO:0051209 IEA     release of sequestered calcium ion into cytosol GO:0051209 ISO     release of sequestered calcium ion into cytosol GO:0051209 ISS     positive regulation of phagocytosis, engulfment GO:0060100 IEA     positive regulation of phagocytosis, engulfment GO:0060100 ISO     positive regulation of macrophage cytokine production GO:0060907 IEA     positive regulation of macrophage cytokine production GO:0060907 ISO     antifungal innate immune response GO:0061760 IEA     antifungal innate immune response GO:0061760 ISO     regulation of calcineurin-NFAT signaling cascade GO:0070884 IEA     regulation of calcineurin-NFAT signaling cascade GO:0070884 ISO     cellular response to calcium ion GO:0071277 IEA     cellular response to calcium ion GO:0071277 ISO     cellular response to lipid GO:0071396 ISO     positive regulation of neuroinflammatory response GO:0150078 IEA     positive regulation of neuroinflammatory response GO:0150078 ISO     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IEA     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISO     positive regulation of cell cycle G1/S phase transition GO:1902808 IDA     positive regulation of reactive oxygen species biosynthetic process GO:1903428 IEA     positive regulation of reactive oxygen species biosynthetic process GO:1903428 ISO     positive regulation of I-kappaB phosphorylation GO:1903721 ISO     cellular response to lectin GO:1990858 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     ruffle membrane GO:0032587 IBA     ruffle membrane GO:0032587 IEA     ruffle membrane GO:0032587 ISO     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO     membrane raft GO:0045121 ISS     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     intracellular vesicle GO:0097708 IEA     intracellular vesicle GO:0097708 ISO