Gene description for Plcg2
Gene name phospholipase C, gamma 2
Gene symbol Plcg2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Plcg2
ExoCarta ExoCarta_29337
Entrez Gene 29337
UniProt P24135  
 Plcg2 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Plcg2
Molecular Function
    signal transducer activity GO:0004871 IEA
    phosphatidylinositol phospholipase C activity GO:0004435 ISO
    protein binding GO:0005515 IPI
Biological Process
    B cell differentiation GO:0030183 ISO
    activation of store-operated calcium channel activity GO:0032237 ISO
    B cell receptor signaling pathway GO:0050853 ISO
    response to magnesium ion GO:0032026 IDA
    phosphatidylinositol biosynthetic process GO:0006661 ISS
    regulation of gene expression GO:0010468 ISO
    T cell receptor signaling pathway GO:0050852 ISO
    negative regulation of programmed cell death GO:0043069 ISO
    inositol trisphosphate biosynthetic process GO:0032959 ISO
    follicular B cell differentiation GO:0002316 ISO
    response to lipopolysaccharide GO:0032496 ISO
    phospholipid catabolic process GO:0009395 IEA
    intracellular signal transduction GO:0035556 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IMP
    release of sequestered calcium ion into cytosol GO:0051209 ISS
    response to ATP GO:0033198 IDA
Subcellular Localization
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    intracellular GO:0005622 ISS
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Plcg2 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Plcg2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plcg2 is involved
PathwayEvidenceSource
FCERI mediated Ca+2 mobilization IEA Reactome





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