Gene description for Serpinh1
Gene name serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Gene symbol Serpinh1
Other names/aliases Cbp2
Serpinh2
Species Rattus norvegicus
 Database cross references - Serpinh1
ExoCarta ExoCarta_29345
Vesiclepedia VP_29345
Entrez Gene 29345
UniProt P29457  
 Serpinh1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Serpinh1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    collagen binding GO:0005518 IEA
    collagen binding GO:0005518 TAS
    unfolded protein binding GO:0051082 IEA
    unfolded protein binding GO:0051082 ISO
Biological Process
    chondrocyte development involved in endochondral bone morphogenesis GO:0003433 IEA
    chondrocyte development involved in endochondral bone morphogenesis GO:0003433 ISO
    negative regulation of endopeptidase activity GO:0010951 IBA
    response to organic cyclic compound GO:0014070 IEP
    collagen fibril organization GO:0030199 IBA
    collagen fibril organization GO:0030199 IEA
    collagen fibril organization GO:0030199 ISO
    collagen biosynthetic process GO:0032964 IEA
    collagen biosynthetic process GO:0032964 ISO
    response to vitamin D GO:0033280 IEP
    protein maturation GO:0051604 IEA
    protein maturation GO:0051604 ISO
Subcellular Localization
    extracellular space GO:0005615 IEA
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum lumen GO:0005788 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
    membrane raft GO:0045121 IEA
    membrane raft GO:0045121 ISO
 Experiment description of studies that identified Serpinh1 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Serpinh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sumo3  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Serpinh1 is involved
PathwayEvidenceSource
Collagen biosynthesis and modifying enzymes IEA Reactome
Collagen formation IEA Reactome
Extracellular matrix organization IEA Reactome





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