Gene description for Ubxn1
Gene name UBX domain protein 1
Gene symbol Ubxn1
Other names/aliases 2B28
RGD1309471
Species Rattus norvegicus
 Database cross references - Ubxn1
ExoCarta ExoCarta_293719
Vesiclepedia VP_293719
Entrez Gene 293719
 Ubxn1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Ubxn1
Molecular Function
    protein binding GO:0005515 IPI
    polyubiquitin modification-dependent protein binding GO:0031593 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 IBA
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 ISO
    ubiquitin binding GO:0043130 ISO
    ATPase binding GO:0051117 ISO
    K6-linked polyubiquitin modification-dependent protein binding GO:0071796 ISO
    K6-linked polyubiquitin modification-dependent protein binding GO:0071796 ISS
    proteasome regulatory particle binding GO:1904855 ISO
Biological Process
    negative regulation of protein ubiquitination GO:0031397 IBA
    negative regulation of protein ubiquitination GO:0031397 ISO
    negative regulation of protein ubiquitination GO:0031397 ISS
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IBA
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISS
    negative regulation of protein K48-linked deubiquitination GO:1903094 IBA
    negative regulation of protein K48-linked deubiquitination GO:1903094 ISO
    negative regulation of ERAD pathway GO:1904293 ISO
    negative regulation of ubiquitin-specific protease activity GO:2000157 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 ISO
    cytosol GO:0005829 ISO
    dendrite GO:0030425 IDA
    VCP-NPL4-UFD1 AAA ATPase complex GO:0034098 ISO
    neuronal cell body GO:0043025 IDA
 Experiment description of studies that identified Ubxn1 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Ubxn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rad23b  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Ubxn1 is involved
No pathways found





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