Gene description for Fah
Gene name fumarylacetoacetate hydrolase
Gene symbol Fah
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fah
ExoCarta ExoCarta_29383
Vesiclepedia VP_29383
Entrez Gene 29383
UniProt P25093  
 Fah identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Urine 20535238    
 Gene ontology annotations for Fah
Molecular Function
    fumarylacetoacetase activity GO:0004334 IBA
    fumarylacetoacetase activity GO:0004334 IEA
    fumarylacetoacetase activity GO:0004334 ISO
    fumarylacetoacetase activity GO:0004334 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    arginine catabolic process GO:0006527 IEA
    arginine catabolic process GO:0006527 ISO
    L-phenylalanine catabolic process GO:0006559 IBA
    L-phenylalanine catabolic process GO:0006559 IEA
    tyrosine catabolic process GO:0006572 IBA
    tyrosine catabolic process GO:0006572 IEA
    lipid metabolic process GO:0006629 IEA
    biological_process GO:0008150 ND
    homogentisate catabolic process GO:1902000 IBA
 Experiment description of studies that identified Fah in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fah
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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