Gene description for Col1a1
Gene name	collagen, type I, alpha 1
Gene symbol	Col1a1
Other names/aliases	COLIA1
Species	Rattus norvegicus
Database cross references - Col1a1
ExoCarta	ExoCarta_29393
Vesiclepedia	VP_29393
Entrez Gene	29393
UniProt	P02454
Col1a1 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041

Gene ontology annotations for Col1a1

Molecular Function     protease binding GO:0002020 ISO     extracellular matrix structural constituent GO:0005201 IEA     extracellular matrix structural constituent GO:0005201 ISO     protein binding GO:0005515 IPI     extracellular matrix structural constituent conferring tensile strength GO:0030020 IBA     identical protein binding GO:0042802 ISO     metal ion binding GO:0046872 IEA     platelet-derived growth factor binding GO:0048407 ISO Biological Process     skeletal system development GO:0001501 IBA     skeletal system development GO:0001501 ISO     skeletal system development GO:0001501 ISO     ossification GO:0001503 IBA     ossification GO:0001503 IEP     blood vessel development GO:0001568 IBA     blood vessel development GO:0001568 ISO     blood vessel development GO:0001568 ISO     osteoblast differentiation GO:0001649 ISO     intramembranous ossification GO:0001957 ISO     endochondral ossification GO:0001958 ISO     response to nutrient GO:0007584 IEP     visual perception GO:0007601 ISO     sensory perception of sound GO:0007605 ISO     response to xenobiotic stimulus GO:0009410 IEP     response to mechanical stimulus GO:0009612 IBA     response to mechanical stimulus GO:0009612 IEP     positive regulation of epithelial to mesenchymal transition GO:0010718 ISO     negative regulation of cell-substrate adhesion GO:0010812 ISO     response to organic cyclic compound GO:0014070 IEP     protein transport GO:0015031 ISO     extracellular matrix organization GO:0030198 IBA     collagen fibril organization GO:0030199 ISO     positive regulation of cell migration GO:0030335 ISO     response to nutrient levels GO:0031667 IEP     response to estradiol GO:0032355 IEP     response to insulin GO:0032868 IEP     collagen biosynthetic process GO:0032964 ISO     protein localization to nucleus GO:0034504 ISO     tooth mineralization GO:0034505 ISO     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IDA     response to hydrogen peroxide GO:0042542 IEP     response to peptide hormone GO:0043434 IEP     skin development GO:0043588 IBA     skin development GO:0043588 ISO     skin morphogenesis GO:0043589 ISO     cellular response to fibroblast growth factor stimulus GO:0044344 IEP     positive regulation of DNA-templated transcription GO:0045893 ISO     response to steroid hormone GO:0048545 IEP     skeletal system morphogenesis GO:0048705 ISO     embryonic skeletal system development GO:0048706 ISO     response to cAMP GO:0051591 IEP     response to hyperoxia GO:0055093 IEP     face morphogenesis GO:0060325 ISO     bone trabecula formation GO:0060346 ISO     cartilage development involved in endochondral bone morphogenesis GO:0060351 ISO     cellular response to amino acid stimulus GO:0071230 ISO     cellular response to mechanical stimulus GO:0071260 IEP     cellular response to mechanical stimulus GO:0071260 ISO     cellular response to retinoic acid GO:0071300 IEP     cellular response to vitamin E GO:0071306 IEP     cellular response to glucose stimulus GO:0071333 IEP     cellular response to tumor necrosis factor GO:0071356 IEP     cellular response to epidermal growth factor stimulus GO:0071364 IEP     cellular response to transforming growth factor beta stimulus GO:0071560 IEP     positive regulation of canonical Wnt signaling pathway GO:0090263 ISO     response to fluoride GO:1902617 IEP     cellular response to fluoride GO:1902618 IEP Subcellular Localization     extracellular region GO:0005576 IEA     extracellular region GO:0005576 TAS     collagen trimer GO:0005581 IEA     collagen trimer GO:0005581 ISO     collagen type I trimer GO:0005584 IBA     collagen type I trimer GO:0005584 ISO     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     secretory granule GO:0030141 IDA     extracellular matrix GO:0031012 ISO     collagen-containing extracellular matrix GO:0062023 IBA     collagen-containing extracellular matrix GO:0062023 ISO