Gene description for Col1a1
Gene name collagen, type I, alpha 1
Gene symbol Col1a1
Other names/aliases COLIA1
Species Rattus norvegicus
 Database cross references - Col1a1
ExoCarta ExoCarta_29393
Entrez Gene 29393
UniProt P02454  
 Col1a1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Col1a1
Molecular Function
    protein binding GO:0005515 IPI
    extracellular matrix structural constituent GO:0005201 ISO
    molecular_function GO:0003674 ND
    metal ion binding GO:0046872 IEA
    platelet-derived growth factor binding GO:0048407 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    response to hyperoxia GO:0055093 IEP
    cellular response to fluoride GO:1902618 IEP
    visual perception GO:0007601 ISO
    osteoblast differentiation GO:0001649 IEA
    response to peptide hormone GO:0043434 IEP
    protein heterotrimerization GO:0070208 ISO
    wound healing GO:0042060 IMP
    response to corticosteroid GO:0031960 IEP
    negative regulation of cell-substrate adhesion GO:0010812 ISO
    cartilage development involved in endochondral bone morphogenesis GO:0060351 ISO
    response to nutrient GO:0007584 IEP
    tooth mineralization GO:0034505 ISO
    face morphogenesis GO:0060325 ISO
    response to nutrient levels GO:0031667 IEP
    cellular response to amino acid stimulus GO:0071230 ISO
    embryonic skeletal system development GO:0048706 ISO
    ossification GO:0001503 IEP
    protein transport GO:0015031 ISO
    cellular response to retinoic acid GO:0071300 IEP
    protein localization to nucleus GO:0034504 ISO
    collagen fibril organization GO:0030199 ISO
    response to drug GO:0042493 IEP
    cellular response to vitamin E GO:0071306 IEP
    sensory perception of sound GO:0007605 ISO
    cellular response to fibroblast growth factor stimulus GO:0044344 IEP
    response to hydrogen peroxide GO:0042542 IEP
    skeletal system development GO:0001501 ISO
    cellular response to transforming growth factor beta stimulus GO:0071560 IEP
    cellular response to mechanical stimulus GO:0071260 IEP
    skin development GO:0043588 ISO
    tooth eruption GO:0044691 IEP
    response to mechanical stimulus GO:0009612 IEP
    cellular response to epidermal growth factor stimulus GO:0071364 IEP
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISO
    collagen biosynthetic process GO:0032964 ISO
    bone trabecula formation GO:0060346 ISO
    response to fluoride GO:1902617 IEP
    positive regulation of cell migration GO:0030335 ISO
    blood vessel development GO:0001568 ISO
    response to steroid hormone GO:0048545 IEP
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISO
    response to cAMP GO:0051591 IEP
    response to estradiol GO:0032355 IEP
    skeletal system morphogenesis GO:0048705 ISO
    endochondral ossification GO:0001958 ISO
    skin morphogenesis GO:0043589 ISO
    intramembranous ossification GO:0001957 ISO
    cellular response to tumor necrosis factor GO:0071356 IEP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 ISO
    collagen type I trimer GO:0005584 ISO
    collagen trimer GO:0005581 ISO
    proteinaceous extracellular matrix GO:0005578 ISO
    Golgi apparatus GO:0005794 IDA
    endoplasmic reticulum GO:0005783 IDA
    secretory granule GO:0030141 IDA
 Experiment description of studies that identified Col1a1 in exosomes
Experiment ID 225
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Col1a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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