Gene description for Aadat
Gene name aminoadipate aminotransferase
Gene symbol Aadat
Other names/aliases Kat2
Species Rattus norvegicus
 Database cross references - Aadat
ExoCarta ExoCarta_29416
Entrez Gene 29416
UniProt Q64602  
 Aadat identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Aadat
Molecular Function
    2-aminoadipate transaminase activity GO:0047536 ISS
    transaminase activity GO:0008483 TAS
    protein homodimerization activity GO:0042803 ISO
    pyridoxal phosphate binding GO:0030170 IMP
    kynurenine-oxoglutarate transaminase activity GO:0016212 ISS
Biological Process
    tryptophan catabolic process to kynurenine GO:0019441 IDA
    L-lysine catabolic process to acetyl-CoA via saccharopine GO:0033512 IEA
    2-oxoglutarate metabolic process GO:0006103 ISS
    kynurenine metabolic process GO:0070189 ISS
    biosynthetic process GO:0009058 IEA
    L-kynurenine metabolic process GO:0097052 ISS
    glutamate metabolic process GO:0006536 ISS
Subcellular Localization
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Aadat in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aadat
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aadat is involved
PathwayEvidenceSource
Lysine catabolism IEA Reactome
Tryptophan catabolism IEA Reactome





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