Gene description for Aadat
Gene name aminoadipate aminotransferase
Gene symbol Aadat
Other names/aliases Kat2
Species Rattus norvegicus
 Database cross references - Aadat
ExoCarta ExoCarta_29416
Vesiclepedia VP_29416
Entrez Gene 29416
UniProt Q64602  
 Aadat identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Aadat
Molecular Function
    transaminase activity GO:0008483 TAS
    kynurenine-oxoglutarate transaminase activity GO:0016212 IBA
    kynurenine-oxoglutarate transaminase activity GO:0016212 IDA
    kynurenine-oxoglutarate transaminase activity GO:0016212 IEA
    kynurenine-oxoglutarate transaminase activity GO:0016212 ISO
    kynurenine-oxoglutarate transaminase activity GO:0016212 ISS
    pyridoxal phosphate binding GO:0030170 IEA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    kynurenine-glyoxylate transaminase activity GO:0047315 IDA
    kynurenine-glyoxylate transaminase activity GO:0047315 IEA
    kynurenine-glyoxylate transaminase activity GO:0047315 ISO
    kynurenine-glyoxylate transaminase activity GO:0047315 ISS
    2-aminoadipate transaminase activity GO:0047536 IDA
    2-aminoadipate transaminase activity GO:0047536 IEA
    2-aminoadipate transaminase activity GO:0047536 ISO
    2-aminoadipate transaminase activity GO:0047536 ISS
    glycine:2-oxoglutarate aminotransferase activity GO:0047958 IEA
    glycine:2-oxoglutarate aminotransferase activity GO:0047958 ISO
    glycine:2-oxoglutarate aminotransferase activity GO:0047958 ISS
    methionine-glyoxylate transaminase activity GO:0050094 IEA
    methionine-glyoxylate transaminase activity GO:0050094 ISO
    methionine-glyoxylate transaminase activity GO:0050094 ISS
Biological Process
    2-oxoglutarate metabolic process GO:0006103 IEA
    2-oxoglutarate metabolic process GO:0006103 ISO
    2-oxoglutarate metabolic process GO:0006103 ISS
    glutamate metabolic process GO:0006536 IEA
    glutamate metabolic process GO:0006536 ISO
    glutamate metabolic process GO:0006536 ISS
    biosynthetic process GO:0009058 IEA
    L-lysine catabolic process to acetyl-CoA via saccharopine GO:0033512 IEA
    kynurenine metabolic process GO:0070189 IEA
    kynurenine metabolic process GO:0070189 ISO
    kynurenine metabolic process GO:0070189 ISS
    alpha-amino acid metabolic process GO:1901605 IBA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    mitochondrial matrix GO:0005759 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Aadat in sEVs
1
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aadat
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aadat is involved
PathwayEvidenceSource
Lysine catabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Tryptophan catabolism IEA Reactome





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