Gene description for Col6a1
Gene name collagen, type VI, alpha 1
Gene symbol Col6a1
Other names/aliases RGD1565398
Species Rattus norvegicus
 Database cross references - Col6a1
ExoCarta ExoCarta_294337
Vesiclepedia VP_294337
Entrez Gene 294337
 Col6a1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Col6a1
Molecular Function
    collagen binding GO:0005518 ISO
    extracellular matrix structural constituent conferring tensile strength GO:0030020 IBA
    platelet-derived growth factor binding GO:0048407 ISO
Biological Process
    response to reactive oxygen species GO:0000302 ISO
    cell morphogenesis GO:0000902 ISO
    ossification GO:0001503 ISO
    hair follicle development GO:0001942 ISO
    reduction of food intake in response to dietary excess GO:0002023 ISO
    muscle system process GO:0003012 ISO
    respiratory system process GO:0003016 ISO
    glycolytic process GO:0006096 ISO
    tricarboxylic acid cycle GO:0006099 ISO
    2-oxoglutarate metabolic process GO:0006103 ISO
    energy reserve metabolic process GO:0006112 ISO
    protein phosphorylation GO:0006468 ISO
    protein lipidation GO:0006497 ISO
    autophagy GO:0006914 ISO
    apoptotic process GO:0006915 ISO
    inflammatory response GO:0006954 ISO
    mitochondrion organization GO:0007005 ISO
    single fertilization GO:0007338 ISO
    peripheral nervous system development GO:0007422 ISO
    heart development GO:0007507 ISO
    muscle organ development GO:0007517 ISO
    skeletal muscle tissue development GO:0007519 ISO
    circadian rhythm GO:0007623 ISO
    biological_process GO:0008150 ND
    insulin receptor signaling pathway GO:0008286 ISO
    regulation of cell size GO:0008361 ISO
    response to xenobiotic stimulus GO:0009410 ISO
    response to UV GO:0009411 ISO
    response to wounding GO:0009611 ISO
    response to mechanical stimulus GO:0009612 ISO
    response to toxic substance GO:0009636 ISO
    gene expression GO:0010467 ISO
    muscle cell apoptotic process GO:0010657 ISO
    response to activity GO:0014823 ISO
    response to muscle activity GO:0014850 ISO
    transmission of nerve impulse GO:0019226 ISO
    myelination in peripheral nervous system GO:0022011 ISO
    extracellular matrix organization GO:0030198 IBA
    collagen fibril organization GO:0030199 ISO
    apoptotic nuclear changes GO:0030262 ISO
    bone mineralization GO:0030282 ISO
    lung development GO:0030324 ISO
    response to lipopolysaccharide GO:0032496 ISO
    collagen metabolic process GO:0032963 ISO
    response to lipid GO:0033993 ISO
    endodermal cell differentiation GO:0035987 ISO
    limb joint morphogenesis GO:0036022 ISO
    response to decreased oxygen levels GO:0036293 ISO
    skeletal muscle tissue regeneration GO:0043403 ISO
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISO
    skin development GO:0043588 ISO
    insulin-like growth factor receptor signaling pathway GO:0048009 ISO
    response to pain GO:0048265 ISO
    lung alveolus development GO:0048286 ISO
    skeletal muscle tissue growth GO:0048630 ISO
    skeletal muscle fiber development GO:0048741 ISO
    tissue remodeling GO:0048771 ISO
    homeostasis of number of cells GO:0048872 ISO
    nervous system process GO:0050877 ISO
    sensory perception of mechanical stimulus GO:0050954 ISO
    cartilage development GO:0051216 ISO
    protein tetramerization GO:0051262 ISO
    neuron apoptotic process GO:0051402 ISO
    mitochondrial depolarization GO:0051882 ISO
    muscle cell development GO:0055001 ISO
    uterus development GO:0060065 ISO
    canonical Wnt signaling pathway GO:0060070 ISO
    bone development GO:0060348 ISO
    lung morphogenesis GO:0060425 ISO
    lung epithelial cell differentiation GO:0060487 ISO
    skeletal muscle organ development GO:0060538 ISO
    adipose tissue development GO:0060612 ISO
    muscle structure development GO:0061061 ISO
    fat cell proliferation GO:0070341 ISO
    caveola assembly GO:0070836 ISO
    cellular response to amino acid stimulus GO:0071230 ISO
    basement membrane organization GO:0071711 ISO
    multicellular organismal locomotion GO:0071965 ISO
    reactive oxygen species metabolic process GO:0072593 ISO
    extracellular matrix assembly GO:0085029 ISO
    energy homeostasis GO:0097009 ISO
    skeletal muscle fiber differentiation GO:0098528 ISO
    response to peptide GO:1901652 ISO
    regulation of collagen fibril organization GO:1904026 ISO
    response to polyamine macromolecule GO:1904583 ISO
    response to bleomycin GO:1904975 ISO
    mitochondrial transmembrane transport GO:1990542 ISO
Subcellular Localization
    extracellular region GO:0005576 ISO
    extracellular region GO:0005576 TAS
    basement membrane GO:0005604 IBA
    basement membrane GO:0005604 ISO
    extracellular space GO:0005615 IBA
    mitochondrion GO:0005739 IEA
    lysosome GO:0005764 ISO
    sarcoplasmic reticulum GO:0016529 ISO
    myofibril GO:0030016 ISO
    extracellular matrix GO:0031012 ISO
    extracellular matrix GO:0031012 ISO
    protein-containing complex GO:0032991 ISO
    sarcolemma GO:0042383 ISO
    intracellular vesicle GO:0097708 ISO
 Experiment description of studies that identified Col6a1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Col6a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Col6a1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here