Gene description for Por
Gene name P450 (cytochrome) oxidoreductase
Gene symbol Por
Other names/aliases CYPOR
Species Rattus norvegicus
 Database cross references - Por
ExoCarta ExoCarta_29441
Entrez Gene 29441
UniProt P00388  
 Por identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Por
Molecular Function
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 IBA
    hydrolase activity GO:0016787 IDA
    nitric oxide dioxygenase activity GO:0008941 IDA
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 IDA
    FMN binding GO:0010181 IMP
    iron ion binding GO:0005506 IEA
    iron-cytochrome-c reductase activity GO:0047726 IDA
    flavin adenine dinucleotide binding GO:0050660 IMP
    NADP binding GO:0050661 IMP
    NADPH-hemoprotein reductase activity GO:0003958 ISO
    electron carrier activity GO:0009055 IDA
    enzyme binding GO:0019899 IPI
    oxidoreductase activity GO:0016491 ISO
Biological Process
    positive regulation of monooxygenase activity GO:0032770 ISO
    positive regulation of chondrocyte differentiation GO:0032332 IMP
    oxidation-reduction process GO:0055114 ISO
    negative regulation of lipase activity GO:0060192 IDA
    carnitine metabolic process GO:0009437 IEP
    fatty acid oxidation GO:0019395 IDA
    nitrate catabolic process GO:0043602 IDA
    regulation of cholesterol metabolic process GO:0090181 IMP
    response to drug GO:0042493 IEP
    response to nutrient GO:0007584 IEP
    regulation of growth plate cartilage chondrocyte proliferation GO:0003420 IMP
    demethylation GO:0070988 IDA
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IEP
    negative regulation of apoptotic process GO:0043066 IMP
    internal peptidyl-lysine acetylation GO:0018393 IDA
    positive regulation of steroid hormone biosynthetic process GO:0090031 IDA
    cellular organofluorine metabolic process GO:0090346 ISO
    cellular response to gonadotropin stimulus GO:0071371 IEP
    cellular response to peptide hormone stimulus GO:0071375 IEP
    positive regulation of cholesterol biosynthetic process GO:0045542 IMP
    nitric oxide catabolic process GO:0046210 IMP
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IMP
    flavonoid metabolic process GO:0009812 IEP
    positive regulation of smoothened signaling pathway GO:0045880 IMP
Subcellular Localization
    membrane GO:0016020 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified Por in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Por
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Por is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here