Gene description for Por
Gene name P450 (cytochrome) oxidoreductase
Gene symbol Por
Other names/aliases CYPOR
Species Rattus norvegicus
 Database cross references - Por
ExoCarta ExoCarta_29441
Vesiclepedia VP_29441
Entrez Gene 29441
UniProt P00388  
 Por identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Por
Molecular Function
    NADPH-hemoprotein reductase activity GO:0003958 IBA
    NADPH-hemoprotein reductase activity GO:0003958 IDA
    NADPH-hemoprotein reductase activity GO:0003958 IEA
    NADPH-hemoprotein reductase activity GO:0003958 IMP
    NADPH-hemoprotein reductase activity GO:0003958 ISO
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 IDA
    nitric oxide dioxygenase NAD(P)H activity GO:0008941 IDA
    electron transfer activity GO:0009055 IDA
    FMN binding GO:0010181 IBA
    FMN binding GO:0010181 IEA
    FMN binding GO:0010181 IMP
    oxidoreductase activity GO:0016491 ISO
    hydrolase activity GO:0016787 IDA
    enzyme binding GO:0019899 IDA
    enzyme binding GO:0019899 IMP
    enzyme binding GO:0019899 IPI
    iron-cytochrome-c reductase activity GO:0047726 IDA
    flavin adenine dinucleotide binding GO:0050660 IBA
    flavin adenine dinucleotide binding GO:0050660 IEA
    flavin adenine dinucleotide binding GO:0050660 IMP
    NADP binding GO:0050661 IDA
    NADP binding GO:0050661 IEA
    NADP binding GO:0050661 IMP
Biological Process
    nitric oxide biosynthetic process GO:0006809 IBA
    response to nutrient GO:0007584 IEP
    response to xenobiotic stimulus GO:0009410 IEP
    carnitine metabolic process GO:0009437 IEP
    response to hormone GO:0009725 IBA
    flavonoid metabolic process GO:0009812 IEP
    internal peptidyl-lysine acetylation GO:0018393 IDA
    fatty acid oxidation GO:0019395 IDA
    electron transport chain GO:0022900 IEA
    electron transport chain GO:0022900 ISO
    positive regulation of chondrocyte differentiation GO:0032332 IMP
    positive regulation of monooxygenase activity GO:0032770 ISO
    negative regulation of apoptotic process GO:0043066 IMP
    nitrate catabolic process GO:0043602 IDA
    positive regulation of smoothened signaling pathway GO:0045880 IMP
    nitric oxide catabolic process GO:0046210 IDA
    nitric oxide catabolic process GO:0046210 IMP
    negative regulation of lipase activity GO:0060192 IDA
    positive regulation of growth plate cartilage chondrocyte proliferation GO:0061913 IMP
    demethylation GO:0070988 IDA
    cellular response to gonadotropin stimulus GO:0071371 IEP
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IEP
    cellular response to peptide hormone stimulus GO:0071375 IEP
    response to dexamethasone GO:0071548 IDA
    positive regulation of steroid hormone biosynthetic process GO:0090031 IDA
    organofluorine metabolic process GO:0090346 IEA
    organofluorine metabolic process GO:0090346 ISO
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    cytosol GO:0005829 IBA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Por in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Por
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Por is involved
No pathways found





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