Gene description for Serinc1
Gene name serine incorporator 1
Gene symbol Serinc1
Other names/aliases LRRGT00191
Tde1l
Tde2
Species Rattus norvegicus
 Database cross references - Serinc1
ExoCarta ExoCarta_294421
Vesiclepedia VP_294421
Entrez Gene 294421
UniProt Q7TNK0  
 Serinc1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Serinc1
Molecular Function
    acetyltransferase activator activity GO:0010698 IDA
    enzyme binding GO:0019899 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
Biological Process
    phosphatidylserine metabolic process GO:0006658 IDA
    sphingolipid metabolic process GO:0006665 IDA
    phospholipid biosynthetic process GO:0008654 IEA
    membrane biogenesis GO:0044091 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IBA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Serinc1 in sEVs
1
Experiment ID 90
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70|HSP90|TSG101|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Serinc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serinc1 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Serine biosynthesis IEA Reactome





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