Gene description for Ptp4a1
Gene name protein tyrosine phosphatase type IVA, member 1
Gene symbol Ptp4a1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ptp4a1
ExoCarta ExoCarta_29463
Entrez Gene 29463
UniProt Q78EG7  
 Ptp4a1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Ptp4a1
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IDA
Biological Process
    multicellular organismal development GO:0007275 IEA
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
    positive regulation of cell migration GO:0030335 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    endoplasmic reticulum GO:0005783 IEA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISO
    spindle GO:0005819 IEA
    early endosome GO:0005769 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Ptp4a1 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ptp4a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptp4a1 is involved
No pathways found





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