Gene description for Aoc3
Gene name amine oxidase, copper containing 3
Gene symbol Aoc3
Other names/aliases SSAO
Species Rattus norvegicus
 Database cross references - Aoc3
ExoCarta ExoCarta_29473
Vesiclepedia VP_29473
Entrez Gene 29473
UniProt O08590  
 Aoc3 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Aoc3
Molecular Function
    copper ion binding GO:0005507 IBA
    copper ion binding GO:0005507 ISO
    calcium ion binding GO:0005509 ISO
    primary methylamine oxidase activity GO:0008131 IDA
    primary methylamine oxidase activity GO:0008131 ISO
    primary methylamine oxidase activity GO:0008131 ISO
    primary methylamine oxidase activity GO:0008131 ISS
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein heterodimerization activity GO:0046982 ISO
    quinone binding GO:0048038 ISO
    quinone binding GO:0048038 ISS
    aliphatic amine oxidase activity GO:0052595 IEA
Biological Process
    leukocyte migration involved in inflammatory response GO:0002523 IMP
    positive regulation of acute inflammatory response GO:0002675 IMP
    positive regulation of leukocyte migration GO:0002687 IMP
    cell adhesion GO:0007155 ISO
    cell adhesion GO:0007155 ISS
    regulation of blood pressure GO:0008217 IMP
    amine metabolic process GO:0009308 IBA
    amine metabolic process GO:0009308 ISO
    amine metabolic process GO:0009308 ISS
    positive regulation of D-glucose transmembrane transport GO:0010828 IDA
    response to immobilization stress GO:0035902 IMP
    eating behavior GO:0042755 IMP
Subcellular Localization
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 ISO
    early endosome GO:0005769 IBA
    early endosome GO:0005769 ISO
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    microvillus GO:0005902 ISO
    cell surface GO:0009986 ISO
    cell surface GO:0009986 ISS
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
 Experiment description of studies that identified Aoc3 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 92
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
3
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Aoc3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aoc3 is involved
PathwayEvidenceSource
Biological oxidations IEA Reactome
Metabolism IEA Reactome
Phase I - Functionalization of compounds IEA Reactome





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