Gene description for Pelo
Gene name pelota homolog (Drosophila)
Gene symbol Pelo
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pelo
ExoCarta ExoCarta_294754
Vesiclepedia VP_294754
Entrez Gene 294754
UniProt Q5XIP1  
 Pelo identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Pelo
Molecular Function
    ribosome binding GO:0043022 ISO
    ribosome binding GO:0043022 ISS
    metal ion binding GO:0046872 IEA
    nucleoside-triphosphatase regulator activity GO:0060589 ISO
    stalled ribosome sensor activity GO:0170011 ISO
Biological Process
    inner cell mass cell proliferation GO:0001833 ISO
    regulation of translation GO:0006417 IEA
    endoderm development GO:0007492 ISO
    biological_process GO:0008150 ND
    stem cell population maintenance GO:0019827 ISO
    positive regulation of BMP signaling pathway GO:0030513 ISO
    ribosome disassembly GO:0032790 IBA
    ribosome disassembly GO:0032790 ISO
    ribosome disassembly GO:0032790 ISS
    chromosome organization GO:0051276 ISO
    cell division GO:0051301 IEA
    mesenchymal to epithelial transition GO:0060231 ISO
    nuclear-transcribed mRNA catabolic process, non-stop decay GO:0070481 IEA
    nonfunctional rRNA decay GO:0070651 IBA
    nuclear-transcribed mRNA catabolic process, no-go decay GO:0070966 IBA
    nuclear-transcribed mRNA catabolic process, no-go decay GO:0070966 ISO
    nuclear-transcribed mRNA catabolic process, no-go decay GO:0070966 ISS
    RNA surveillance GO:0071025 IEA
    rescue of stalled ribosome GO:0072344 ISO
    rescue of stalled ribosome GO:0072344 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosolic ribosome GO:0022626 ISO
    Dom34-Hbs1 complex GO:1990533 ISO
    Dom34-Hbs1 complex GO:1990533 ISS
 Experiment description of studies that identified Pelo in sEVs
1
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Pelo
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pelo is involved
No pathways found





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