Gene description for Padi4
Gene name peptidyl arginine deiminase, type IV
Gene symbol Padi4
Other names/aliases Pdi4
Species Rattus norvegicus
 Database cross references - Padi4
ExoCarta ExoCarta_29512
Entrez Gene 29512
UniProt O88807  
 Padi4 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Padi4
Molecular Function
    protein-arginine deiminase activity GO:0004668 ISO
    arginine deiminase activity GO:0016990 ISO
    calcium ion binding GO:0005509 ISS
Biological Process
    protein citrullination GO:0018101 ISO
    innate immune response GO:0045087 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    chromatin modification GO:0016568 ISS
    histone H3-R26 citrullination GO:0036413 ISS
    stem cell maintenance GO:0019827 ISS
    chromatin remodeling GO:0006338 ISS
    transcription, DNA-templated GO:0006351 IEA
    histone citrullination GO:0036414 ISS
    nucleosome assembly GO:0006334 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified Padi4 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Padi4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Padi4 is involved
No pathways found





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