Gene description for Padi4
Gene name peptidyl arginine deiminase, type IV
Gene symbol Padi4
Other names/aliases Pdi4
Species Rattus norvegicus
 Database cross references - Padi4
ExoCarta ExoCarta_29512
Vesiclepedia VP_29512
Entrez Gene 29512
UniProt O88807  
 Padi4 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Padi4
Molecular Function
    protein-arginine deiminase activity GO:0004668 IDA
    protein-arginine deiminase activity GO:0004668 IEA
    protein-arginine deiminase activity GO:0004668 ISO
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    identical protein binding GO:0042802 ISO
    histone arginine deiminase activity GO:0140794 IBA
    histone arginine deiminase activity GO:0140794 ISO
    histone H3R2 arginine deiminase activity GO:0140795 ISO
    histone H3R8 arginine deiminase activity GO:0140796 ISO
    histone H3R17 arginine deiminase activity GO:0140797 ISO
    histone H3R26 arginine deiminase activity GO:0140798 ISO
    histone H4R3 arginine deiminase activity GO:0140809 IEA
    histone H1R54 arginine deiminase activity GO:0140810 IEA
    histone H2AR3 arginine deiminase activity GO:0140811 IEA
Biological Process
    chromatin organization GO:0006325 ISO
    chromatin organization GO:0006325 ISS
    nucleosome assembly GO:0006334 ISO
    nucleosome assembly GO:0006334 ISS
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 ISO
    chromatin remodeling GO:0006338 ISS
    stem cell population maintenance GO:0019827 ISO
    stem cell population maintenance GO:0019827 ISS
    post-translational protein modification GO:0043687 ISO
    innate immune response GO:0045087 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Padi4 in sEVs
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Padi4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Padi4 is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome





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