Gene description for S100a1
Gene name S100 calcium binding protein A1
Gene symbol S100a1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - S100a1
ExoCarta ExoCarta_295214
Entrez Gene 295214
UniProt P35467  
 S100a1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for S100a1
Molecular Function
    ATPase binding GO:0051117 ISO
    calcium-dependent protein binding GO:0048306 IPI
    S100 protein binding GO:0044548 ISO
    protein homodimerization activity GO:0042803 ISO
    identical protein binding GO:0042802 ISO
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IDA
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    regulation of heart contraction GO:0008016 IEA
    positive regulation of voltage-gated calcium channel activity GO:1901387 IDA
    substantia nigra development GO:0021762 ISO
Subcellular Localization
    Z disc GO:0030018 IDA
    nucleus GO:0005634 ISO
    neuron projection GO:0043005 IDA
    sarcoplasmic reticulum GO:0016529 ISO
    I band GO:0031674 IDA
    cytosol GO:0005829 TAS
    M band GO:0031430 IDA
    cytoplasm GO:0005737 IDA
    A band GO:0031672 IDA
 Experiment description of studies that identified S100a1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for S100a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which S100a1 is involved
No pathways found





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