Gene description for Pdha1
Gene name pyruvate dehydrogenase (lipoamide) alpha 1
Gene symbol Pdha1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pdha1
ExoCarta ExoCarta_29554
Entrez Gene 29554
 Pdha1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Pdha1
Molecular Function
    pyruvate dehydrogenase (acetyl-transferring) activity GO:0004739 TAS
    pyruvate dehydrogenase activity GO:0004738 ISS
Biological Process
    acetyl-CoA biosynthetic process from pyruvate GO:0006086 ISO
    tricarboxylic acid cycle GO:0006099 ISS
    glycolytic process GO:0006096 IEA
    oxidation-reduction process GO:0055114 ISO
    glucose metabolic process GO:0006006 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    myelin sheath GO:0043209 ISO
    intracellular membrane-bounded organelle GO:0043231 IEA
    mitochondrial pyruvate dehydrogenase complex GO:0005967 TAS
    nucleus GO:0005634 ISO
    pyruvate dehydrogenase complex GO:0045254 ISO
 Experiment description of studies that identified Pdha1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Pdha1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdha1 is involved
No pathways found





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