Gene description for P2ry2
Gene name purinergic receptor P2Y, G-protein coupled, 2
Gene symbol P2ry2
Other names/aliases P2Y2
Species Rattus norvegicus
 Database cross references - P2ry2
ExoCarta ExoCarta_29597
Entrez Gene 29597
UniProt P41232  
 P2ry2 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for P2ry2
Molecular Function
    protein binding GO:0005515 IPI
    G-protein coupled purinergic nucleotide receptor activity GO:0045028 TAS
    ATP binding GO:0005524 IDA
    UTP-activated nucleotide receptor activity GO:0045030 IDA
    A1 adenosine receptor binding GO:0031686 IPI
Biological Process
    positive regulation of chemokine production GO:0032722 IDA
    aging GO:0007568 IEP
    G-protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 TAS
    positive regulation of prostaglandin secretion GO:0032308 IDA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IMP
    positive regulation of neuron projection development GO:0010976 IDA
    response to growth factor GO:0070848 IEP
    positive regulation of mucus secretion GO:0070257 ISO
    positive regulation of smooth muscle cell migration GO:0014911 IMP
    sensory perception of pain GO:0019233 IDA
    phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IEA
    positive regulation of penile erection GO:0060406 IDA
    cellular response to interleukin-1 GO:0071347 IEP
    wound healing GO:0042060 IEP
    in utero embryonic development GO:0001701 IEP
    cellular response to lipopolysaccharide GO:0071222 IEP
    cellular response to purine-containing compound GO:0071415 IEP
    regulation of vasodilation GO:0042312 IDA
    negative regulation of ossification GO:0030279 IDA
Subcellular Localization
    early endosome GO:0005769 IDA
    mitochondrion GO:0005739 IDA
    apical plasma membrane GO:0016324 IDA
    integral component of membrane GO:0016021 IEA
    cytosol GO:0005829 IMP
    basolateral plasma membrane GO:0016323 IDA
    lysosome GO:0005764 IDA
 Experiment description of studies that identified P2ry2 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for P2ry2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which P2ry2 is involved
No pathways found





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