Gene description for Atp2a2
Gene name ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Gene symbol Atp2a2
Other names/aliases Serca2
SercaII
Species Rattus norvegicus
 Database cross references - Atp2a2
ExoCarta ExoCarta_29693
Entrez Gene 29693
UniProt P11507  
 Atp2a2 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Atp2a2
Molecular Function
    protein binding GO:0005515 IPI
    lutropin-choriogonadotropic hormone receptor binding GO:0031775 IPI
    calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential GO:0086039 IDA
    ATP binding GO:0005524 IEA
    calcium-transporting ATPase activity GO:0005388 ISO
    enzyme binding GO:0019899 ISO
    calcium ion binding GO:0005509 ISO
    S100 protein binding GO:0044548 ISO
    protein C-terminus binding GO:0008022 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    relaxation of cardiac muscle GO:0055119 ISO
    sarcoplasmic reticulum calcium ion transport GO:0070296 ISO
    negative regulation of heart contraction GO:0045822 ISO
    organelle organization GO:0006996 ISO
    response to peptide hormone GO:0043434 IDA
    cellular calcium ion homeostasis GO:0006874 ISO
    regulation of calcium ion-dependent exocytosis of neurotransmitter GO:1903233 ISO
    regulation of the force of heart contraction GO:0002026 ISO
    endoplasmic reticulum calcium ion homeostasis GO:0032469 ISO
    calcium ion transport GO:0006816 IDA
    regulation of muscle contraction GO:0006937 TAS
    calcium ion transmembrane transport GO:0070588 ISO
    regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 IDA
    calcium ion transport from cytosol to endoplasmic reticulum GO:1903515 ISO
    regulation of cardiac muscle cell membrane potential GO:0086036 IDA
    regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 ISO
    metabolic process GO:0008152 IEA
    transition between fast and slow fiber GO:0014883 ISO
    ER-nucleus signaling pathway GO:0006984 ISO
    T-tubule organization GO:0033292 ISO
    response to endoplasmic reticulum stress GO:0034976 IEP
    positive regulation of endoplasmic reticulum calcium ion concentration GO:0032470 ISO
    calcium ion import into sarcoplasmic reticulum GO:1990036 IDA
Subcellular Localization
    membrane GO:0016020 ISO
    integral component of membrane GO:0016021 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    sarcoplasmic reticulum membrane GO:0033017 IEA
    endoplasmic reticulum GO:0005783 ISO
    ribbon synapse GO:0097470 ISO
    vesicle membrane GO:0012506 IDA
    calcium ion-transporting ATPase complex GO:0090534 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    intracellular GO:0005622 ISO
    longitudinal sarcoplasmic reticulum GO:0014801 ISO
    sarcoplasmic reticulum GO:0016529 TAS
    cell GO:0005623 ISO
    intercalated disc GO:0014704 ISO
    protein complex GO:0043234 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA
 Experiment description of studies that identified Atp2a2 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
3
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Atp2a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp2a2 is involved
No pathways found





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