Gene description for Atp2a2
Gene name	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Gene symbol	Atp2a2
Other names/aliases	Serca2 SercaII
Species	Rattus norvegicus
Database cross references - Atp2a2
ExoCarta	ExoCarta_29693
Vesiclepedia	VP_29693
Entrez Gene	29693
UniProt	P11507
Atp2a2 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Atp2a2

Molecular Function     P-type calcium transporter activity GO:0005388 IDA     P-type calcium transporter activity GO:0005388 IEA     P-type calcium transporter activity GO:0005388 ISO     calcium ion binding GO:0005509 IDA     calcium ion binding GO:0005509 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     ATP binding GO:0005524 IEA     ATP hydrolysis activity GO:0016887 IEA     enzyme binding GO:0019899 IEA     enzyme binding GO:0019899 ISO     lutropin-choriogonadotropic hormone receptor binding GO:0031775 IPI     transmembrane transporter binding GO:0044325 ISO     S100 protein binding GO:0044548 ISO     P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential GO:0086039 IBA     P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential GO:0086039 ISO     P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential GO:0086039 ISS     lncRNA binding GO:0106222 IEA     lncRNA binding GO:0106222 ISO Biological Process     autophagosome assembly GO:0000045 IBA     autophagosome assembly GO:0000045 ISO     autophagosome assembly GO:0000045 ISS     regulation of the force of heart contraction GO:0002026 IEA     regulation of the force of heart contraction GO:0002026 ISO     calcium ion transport GO:0006816 IDA     intracellular calcium ion homeostasis GO:0006874 IBA     intracellular calcium ion homeostasis GO:0006874 ISO     intracellular calcium ion homeostasis GO:0006874 ISO     ER-nucleus signaling pathway GO:0006984 IEA     ER-nucleus signaling pathway GO:0006984 ISO     positive regulation of cardiac muscle cell apoptotic process GO:0010666 IEA     positive regulation of cardiac muscle cell apoptotic process GO:0010666 ISO     regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 IBA     regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 IDA     regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 ISO     transition between fast and slow fiber GO:0014883 IEA     transition between fast and slow fiber GO:0014883 ISO     cardiac muscle hypertrophy in response to stress GO:0014898 IEA     cardiac muscle hypertrophy in response to stress GO:0014898 ISO     autophagosome membrane docking GO:0016240 ISO     autophagosome membrane docking GO:0016240 ISS     endoplasmic reticulum calcium ion homeostasis GO:0032469 ISO     positive regulation of endoplasmic reticulum calcium ion concentration GO:0032470 IEA     positive regulation of endoplasmic reticulum calcium ion concentration GO:0032470 ISO     positive regulation of endoplasmic reticulum calcium ion concentration GO:0032470 ISO     response to lipopolysaccharide GO:0032496 IEP     T-tubule organization GO:0033292 IEA     T-tubule organization GO:0033292 ISO     cellular response to oxidative stress GO:0034599 IEA     cellular response to oxidative stress GO:0034599 ISO     cellular response to heat GO:0034605 IEP     response to endoplasmic reticulum stress GO:0034976 IEP     response to peptide hormone GO:0043434 IDA     negative regulation of heart contraction GO:0045822 IEA     negative regulation of heart contraction GO:0045822 ISO     relaxation of cardiac muscle GO:0055119 IDA     relaxation of cardiac muscle GO:0055119 ISO     neuron cellular homeostasis GO:0070050 IEA     neuron cellular homeostasis GO:0070050 ISO     sarcoplasmic reticulum calcium ion transport GO:0070296 IDA     sarcoplasmic reticulum calcium ion transport GO:0070296 ISO     calcium ion transmembrane transport GO:0070588 IBA     calcium ion transmembrane transport GO:0070588 IDA     calcium ion transmembrane transport GO:0070588 IEA     calcium ion transmembrane transport GO:0070588 ISO     regulation of cardiac muscle cell membrane potential GO:0086036 IDA     regulation of cardiac muscle cell membrane potential GO:0086036 ISO     relaxation of skeletal muscle GO:0090076 IEP     regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 IDA     organelle localization by membrane tethering GO:0140056 ISO     organelle localization by membrane tethering GO:0140056 ISS     regulation of calcium ion-dependent exocytosis of neurotransmitter GO:1903233 IEA     regulation of calcium ion-dependent exocytosis of neurotransmitter GO:1903233 ISO     calcium ion transport from cytosol to endoplasmic reticulum GO:1903515 ISO     calcium ion import into sarcoplasmic reticulum GO:1990036 IDA     calcium ion import into sarcoplasmic reticulum GO:1990036 IEA     calcium ion import into sarcoplasmic reticulum GO:1990036 ISO     mitochondrion-endoplasmic reticulum membrane tethering GO:1990456 ISO     mitochondrion-endoplasmic reticulum membrane tethering GO:1990456 ISS Subcellular Localization     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum membrane GO:0005789 ISO     intercalated disc GO:0014704 ISO     longitudinal sarcoplasmic reticulum GO:0014801 ISO     membrane GO:0016020 IBA     membrane GO:0016020 ISO     sarcoplasmic reticulum GO:0016529 IDA     sarcoplasmic reticulum GO:0016529 ISO     sarcoplasmic reticulum GO:0016529 TAS     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA     protein-containing complex GO:0032991 IDA     sarcoplasmic reticulum membrane GO:0033017 IC     sarcoplasmic reticulum membrane GO:0033017 IEA     sarcoplasmic reticulum membrane GO:0033017 ISO     perinuclear region of cytoplasm GO:0048471 IDA     apical ectoplasmic specialization GO:0061831 IDA     calcium ion-transporting ATPase complex GO:0090534 ISO     ribbon synapse GO:0097470 IEA     ribbon synapse GO:0097470 ISO     plasma membrane bounded cell projection GO:0120025 IDA