Gene description for Slc22a5
Gene name solute carrier family 22 (organic cation/carnitine transporter), member 5
Gene symbol Slc22a5
Other names/aliases CT1
OCTN2
UST2r
Species Rattus norvegicus
 Database cross references - Slc22a5
ExoCarta ExoCarta_29726
Vesiclepedia VP_29726
Entrez Gene 29726
UniProt O70594  
 Slc22a5 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc22a5
Molecular Function
    ATP binding GO:0005524 IEA
    amino-acid betaine transmembrane transporter activity GO:0015199 ISO
    amino-acid betaine transmembrane transporter activity GO:0015199 ISS
    carnitine transmembrane transporter activity GO:0015226 IDA
    carnitine transmembrane transporter activity GO:0015226 IMP
    carnitine transmembrane transporter activity GO:0015226 ISO
    symporter activity GO:0015293 IEA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IBA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IDA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IMP
    quaternary ammonium group transmembrane transporter activity GO:0015651 ISO
    transmembrane transporter activity GO:0022857 IEA
    PDZ domain binding GO:0030165 ISO
    (R)-carnitine transmembrane transporter activity GO:1901235 IMP
    (R)-carnitine transmembrane transporter activity GO:1901235 ISO
    (R)-carnitine transmembrane transporter activity GO:1901235 ISO
    (R)-carnitine transmembrane transporter activity GO:1901235 ISS
Biological Process
    sodium ion transport GO:0006814 IEA
    mitochondrion organization GO:0007005 ISO
    adult heart development GO:0007512 ISO
    locomotory behavior GO:0007626 ISO
    carnitine metabolic process GO:0009437 ISO
    quaternary ammonium group transport GO:0015697 IBA
    quaternary ammonium group transport GO:0015697 IDA
    quaternary ammonium group transport GO:0015697 IMP
    quaternary ammonium group transport GO:0015697 ISO
    quaternary ammonium group transport GO:0015697 ISO
    carnitine transport GO:0015879 IDA
    carnitine transport GO:0015879 IMP
    carnitine transport GO:0015879 ISO
    carnitine transport GO:0015879 ISO
    response to type II interferon GO:0034341 ISO
    response to type II interferon GO:0034341 ISS
    response to tumor necrosis factor GO:0034612 ISO
    response to tumor necrosis factor GO:0034612 ISS
    reproductive structure development GO:0048608 ISO
    establishment of localization in cell GO:0051649 ISO
    transmembrane transport GO:0055085 IEA
    positive regulation of intestinal epithelial structure maintenance GO:0060731 ISO
    sodium-dependent organic cation transport GO:0070715 ISO
    transport across blood-brain barrier GO:0150104 ISO
    (R)-carnitine transport GO:1900749 ISO
    (R)-carnitine transport GO:1900749 ISO
    (R)-carnitine transmembrane transport GO:1902270 IDA
    (R)-carnitine transmembrane transport GO:1902270 IMP
    (R)-carnitine transmembrane transport GO:1902270 ISO
Subcellular Localization
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 ISO
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISO
    basal plasma membrane GO:0009925 ISO
    membrane GO:0016020 IEA
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 ISO
    brush border membrane GO:0031526 ISO
 Experiment description of studies that identified Slc22a5 in exosomes
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc22a5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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