Gene description for Slc22a5
Gene name solute carrier family 22 (organic cation/carnitine transporter), member 5
Gene symbol Slc22a5
Other names/aliases CT1
OCTN2
UST2r
Species Rattus norvegicus
 Database cross references - Slc22a5
ExoCarta ExoCarta_29726
Entrez Gene 29726
UniProt O70594  
 Slc22a5 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc22a5
Molecular Function
    ATP binding GO:0005524 IEA
    quaternary ammonium group transmembrane transporter activity GO:0015651 ISO
    antibiotic transporter activity GO:0042895 IMP
    PDZ domain binding GO:0030165 ISO
    cation:cation antiporter activity GO:0015491 IEA
    symporter activity GO:0015293 IEA
    carnitine transmembrane transporter activity GO:0015226 ISO
    protein binding GO:0005515 IPI
Biological Process
    sodium-dependent organic cation transport GO:0070715 ISO
    quaternary ammonium group transport GO:0015697 ISO
    carnitine transmembrane transport GO:1902603 ISO
    modified amino acid transport GO:0072337 ISO
    carnitine metabolic process GO:0009437 ISO
    carnitine transport GO:0015879 ISO
    adult heart development GO:0007512 ISO
    antibiotic transport GO:0042891 IMP
    locomotory behavior GO:0007626 ISO
    positive regulation of intestinal epithelial structure maintenance GO:0060731 ISO
    mitochondrion organization GO:0007005 ISO
    organic cation transport GO:0015695 ISO
    quorum sensing involved in interaction with host GO:0052106 ISO
    triglyceride metabolic process GO:0006641 IEA
    reproductive structure development GO:0048608 ISO
    sodium ion transport GO:0006814 IEA
Subcellular Localization
    apical plasma membrane GO:0016324 ISO
    mitochondrion GO:0005739 IEA
    extracellular exosome GO:0070062 ISO
    basolateral plasma membrane GO:0016323 IDA
    brush border membrane GO:0031526 ISO
    integral component of membrane GO:0016021 NAS
 Experiment description of studies that identified Slc22a5 in exosomes
1
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc22a5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc22a5 is involved
PathwayEvidenceSource
Organic cation transport IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here