Gene description for Gclm
Gene name	glutamate cysteine ligase, modifier subunit
Gene symbol	Gclm
Other names/aliases	Glclr
Species	Rattus norvegicus
Database cross references - Gclm
ExoCarta	ExoCarta_29739
Vesiclepedia	VP_29739
Entrez Gene	29739
UniProt	P48508
Gclm identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Gclm

Molecular Function     glutamate-cysteine ligase activity GO:0004357 IDA     glutamate-cysteine ligase activity GO:0004357 IMP     glutamate-cysteine ligase activity GO:0004357 ISO     glutamate-cysteine ligase catalytic subunit binding GO:0035226 IBA     glutamate-cysteine ligase catalytic subunit binding GO:0035226 IDA     glutamate-cysteine ligase catalytic subunit binding GO:0035226 ISO     glutamate-cysteine ligase catalytic subunit binding GO:0035226 ISS     protein-containing complex binding GO:0044877 IDA     glutamate-cysteine ligase regulator activity GO:1990609 IBA Biological Process     cysteine metabolic process GO:0006534 ISO     glutamate metabolic process GO:0006536 ISO     glutamate metabolic process GO:0006536 ISS     glutathione metabolic process GO:0006749 ISO     glutathione biosynthetic process GO:0006750 IBA     glutathione biosynthetic process GO:0006750 IEA     glutathione biosynthetic process GO:0006750 IMP     glutathione biosynthetic process GO:0006750 ISO     glutathione biosynthetic process GO:0006750 ISO     glutathione biosynthetic process GO:0006750 ISS     response to oxidative stress GO:0006979 IMP     response to oxidative stress GO:0006979 ISO     response to oxidative stress GO:0006979 ISO     response to oxidative stress GO:0006979 ISS     response to nutrient GO:0007584 IEP     apoptotic mitochondrial changes GO:0008637 ISO     response to xenobiotic stimulus GO:0009410 ISO     response to xenobiotic stimulus GO:0009410 ISS     response to activity GO:0014823 IEP     positive regulation of glutamate-cysteine ligase activity GO:0035229 IDA     positive regulation of glutamate-cysteine ligase activity GO:0035229 ISO     cellular response to hepatocyte growth factor stimulus GO:0035729 IEP     hepatic stellate cell activation GO:0035733 IEP     negative regulation of neuron apoptotic process GO:0043524 IMP     cellular response to fibroblast growth factor stimulus GO:0044344 IEP     response to human chorionic gonadotropin GO:0044752 IEP     response to nitrosative stress GO:0051409 IMP     regulation of mitochondrial depolarization GO:0051900 ISO     cellular response to glucose stimulus GO:0071333 IEP     cellular response to follicle-stimulating hormone stimulus GO:0071372 IEP     cellular response to thyroxine stimulus GO:0097069 IEP     blood vessel diameter maintenance GO:0097746 ISO     blood vessel diameter maintenance GO:0097746 ISS     cellular response to leukemia inhibitory factor GO:1990830 ISO     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO Subcellular Localization     glutamate-cysteine ligase complex GO:0017109 IBA     glutamate-cysteine ligase complex GO:0017109 IDA     glutamate-cysteine ligase complex GO:0017109 ISO