Gene description for Atp6v0a1
Gene name ATPase, H+ transporting, lysosomal V0 subunit A1
Gene symbol Atp6v0a1
Other names/aliases Atp6n1
Atp6n1a
Species Rattus norvegicus
 Database cross references - Atp6v0a1
ExoCarta ExoCarta_29757
Entrez Gene 29757
UniProt P25286  
 Atp6v0a1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Atp6v0a1
Molecular Function
    ATPase binding GO:0051117 ISO
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IBA
    molecular_function GO:0003674 ND
Biological Process
    ATP synthesis coupled proton transport GO:0015986 IBA
    toxin transport GO:1901998 ISO
    biological_process GO:0008150 ND
    ATP hydrolysis coupled proton transport GO:0015991 IEA
    vacuolar acidification GO:0007035 IBA
    vacuolar proton-transporting V-type ATPase complex assembly GO:0070072 IBA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasmic vesicle membrane GO:0030659 IEA
    terminal bouton GO:0043195 IDA
    melanosome GO:0042470 IEA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 ISO
    vacuolar proton-transporting V-type ATPase complex GO:0016471 IBA
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular exosome GO:0070062 ISO
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 ISO
    vacuolar proton-transporting V-type ATPase, V0 domain GO:0000220 IEA
    Golgi apparatus GO:0005794 ISO
 Experiment description of studies that identified Atp6v0a1 in exosomes
1
Experiment ID 99
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 100
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 101
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Atp6v0a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp6v0a1 is involved
No pathways found





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