Gene description for Strap
Gene name serine/threonine kinase receptor associated protein
Gene symbol Strap
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Strap
ExoCarta ExoCarta_297699
Entrez Gene 297699
UniProt Q5XIG8  
 Strap identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Strap
Molecular Function
    receptor binding GO:0005102 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    maintenance of gastrointestinal epithelium GO:0030277 ISO
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    spliceosomal snRNP assembly GO:0000387 ISS
    negative regulation of epithelial cell migration GO:0010633 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    negative regulation of epithelial cell proliferation GO:0050680 ISO
    negative regulation of pathway-restricted SMAD protein phosphorylation GO:0060394 ISO
    negative regulation of epithelial to mesenchymal transition GO:0010719 ISO
Subcellular Localization
    SMN-Sm protein complex GO:0034719 ISS
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISS
    SMN complex GO:0032797 ISS
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Strap in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Strap
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Strap is involved
PathwayEvidenceSource
Downregulation of TGF-beta receptor signaling IEA Reactome





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