Gene description for Rragc
Gene name Ras-related GTP binding C
Gene symbol Rragc
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rragc
ExoCarta ExoCarta_298514
Vesiclepedia VP_298514
Entrez Gene 298514
 Rragc identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Rragc
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 ISO
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 ISO
    GDP binding GO:0019003 ISO
    protein-membrane adaptor activity GO:0043495 ISO
    protein heterodimerization activity GO:0046982 ISO
    GTPase binding GO:0051020 ISO
    molecular adaptor activity GO:0060090 ISO
    enzyme-substrate adaptor activity GO:0140767 ISO
Biological Process
    biological_process GO:0008150 ND
    cellular response to starvation GO:0009267 IBA
    negative regulation of autophagy GO:0010507 IBA
    cellular response to nutrient levels GO:0031669 ISO
    regulation of TOR signaling GO:0032006 ISO
    cellular response to amino acid starvation GO:0034198 ISO
    response to amino acid GO:0043200 ISO
    protein localization to lysosome GO:0061462 ISO
    cellular response to amino acid stimulus GO:0071230 IEA
    protein localization to membrane GO:0072657 ISO
    regulation of TORC1 signaling GO:1903432 ISO
    positive regulation of TORC1 signaling GO:1904263 IBA
    positive regulation of TORC1 signaling GO:1904263 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    lysosome GO:0005764 IBA
    lysosome GO:0005764 ISO
    lysosomal membrane GO:0005765 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    Gtr1-Gtr2 GTPase complex GO:1990131 IBA
    FNIP-folliculin RagC/D GAP GO:1990877 ISO
 Experiment description of studies that identified Rragc in sEVs
1
Experiment ID 96
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rragc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rragc is involved
No pathways found





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