Gene description for Capzb
Gene name capping protein (actin filament) muscle Z-line, beta
Gene symbol Capzb
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Capzb
ExoCarta ExoCarta_298584
Entrez Gene 298584
UniProt Q5XI32  
 Capzb identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Capzb
Molecular Function
    actin filament binding GO:0051015 ISO
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
    beta-tubulin binding GO:0048487 ISO
Biological Process
    negative regulation of microtubule polymerization GO:0031115 ISO
    cytoskeleton organization GO:0007010 ISS
    barbed-end actin filament capping GO:0051016 ISO
    biological_process GO:0008150 ND
    regulation of lamellipodium assembly GO:0010591 IBA
    actin cytoskeleton organization GO:0030036 IEA
    regulation of cell morphogenesis GO:0022604 ISS
    cell morphogenesis GO:0000902 IBA
    lamellipodium assembly GO:0030032 ISO
    muscle fiber development GO:0048747 ISO
    cell projection organization GO:0030030 ISO
    regulation of protein kinase C signaling GO:0090036 ISO
    neuron projection development GO:0031175 ISO
    negative regulation of filopodium assembly GO:0051490 IBA
Subcellular Localization
    Z disc GO:0030018 ISO
    acrosomal vesicle GO:0001669 ISO
    cortical cytoskeleton GO:0030863 ISO
    lamellipodium GO:0030027 ISO
    extracellular exosome GO:0070062 ISO
    actin filament GO:0005884 IBA
    brush border GO:0005903 ISO
    WASH complex GO:0071203 ISS
    membrane GO:0016020 ISO
    neuronal cell body GO:0043025 IDA
    F-actin capping protein complex GO:0008290 ISO
    dendritic spine GO:0043197 IDA
    intercalated disc GO:0014704 ISO
 Experiment description of studies that identified Capzb in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Capzb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Capzb is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here