Gene description for Sdhb
Gene name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene symbol
Sdhb
Other names/aliases
-
Species
Rattus norvegicus
Database cross references - Sdhb
ExoCarta
ExoCarta_298596
Vesiclepedia
VP_298596
Entrez Gene
298596
UniProt
P21913
Sdhb identified in sEVs derived from the following tissue/cell type
Reticulocytes
21828046
Reticulocytes
21828046
Gene ontology annotations for Sdhb
Molecular Function
succinate dehydrogenase (quinone) activity
GO:0008177
IEA
succinate dehydrogenase (quinone) activity
GO:0008177
IMP
succinate dehydrogenase (quinone) activity
GO:0008177
ISO
succinate dehydrogenase (quinone) activity
GO:0008177
ISS
electron transfer activity
GO:0009055
IEA
oxidoreductase activity
GO:0016491
IEA
metal ion binding
GO:0046872
IEA
ubiquinone binding
GO:0048039
ISO
ubiquinone binding
GO:0048039
ISS
2 iron, 2 sulfur cluster binding
GO:0051537
IEA
2 iron, 2 sulfur cluster binding
GO:0051537
ISO
2 iron, 2 sulfur cluster binding
GO:0051537
ISS
3 iron, 4 sulfur cluster binding
GO:0051538
IEA
3 iron, 4 sulfur cluster binding
GO:0051538
ISO
3 iron, 4 sulfur cluster binding
GO:0051538
ISS
4 iron, 4 sulfur cluster binding
GO:0051539
IEA
4 iron, 4 sulfur cluster binding
GO:0051539
ISO
4 iron, 4 sulfur cluster binding
GO:0051539
ISS
Biological Process
tricarboxylic acid cycle
GO:0006099
IEA
tricarboxylic acid cycle
GO:0006099
NAS
succinate metabolic process
GO:0006105
IMP
mitochondrial electron transport, succinate to ubiquinone
GO:0006121
NAS
aerobic respiration
GO:0009060
IBA
respiratory electron transport chain
GO:0022904
IBA
respiratory electron transport chain
GO:0022904
IMP
proton motive force-driven mitochondrial ATP synthesis
GO:0042776
NAS
Subcellular Localization
nucleoplasm
GO:0005654
IEA
nucleoplasm
GO:0005654
ISO
mitochondrion
GO:0005739
ISO
mitochondrial inner membrane
GO:0005743
IDA
mitochondrial inner membrane
GO:0005743
IEA
mitochondrial inner membrane
GO:0005743
ISO
mitochondrial inner membrane
GO:0005743
ISS
mitochondrial inner membrane
GO:0005743
NAS
plasma membrane
GO:0005886
IEA
plasma membrane
GO:0005886
ISO
mitochondrial membrane
GO:0031966
IBA
respiratory chain complex II (succinate dehydrogenase)
GO:0045273
IEA
respiratory chain complex II (succinate dehydrogenase)
GO:0045273
ISO
respiratory chain complex II (succinate dehydrogenase)
GO:0045273
ISS
Experiment description of studies that identified Sdhb in sEVs
1
Experiment ID
97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry [Orbitrap]
PubMed ID
21828046
Organism
Rattus norvegicus
Experiment description
The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors
"Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name
JBC
Publication year
2011
Sample
Reticulocytes
Sample name
Reticulocytes - D4 Rep 2
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.16-1.21 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting
2
Experiment ID
98
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry [Orbitrap]
PubMed ID
21828046
Organism
Rattus norvegicus
Experiment description
The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors
"Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name
JBC
Publication year
2011
Sample
Reticulocytes
Sample name
Reticulocytes - D7 Rep 2
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.25 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Mass spectrometry [QSTAR] Mass spectrometry [Orbitrap] Western blotting
Protein-protein interactions for Sdhb
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
Dao
Affinity Capture-MS
Rattus norvegicus
2
Itm2b
290364
Affinity Capture-MS
Rattus norvegicus
View the network
image/svg+xml
Pathways in which Sdhb is involved