Gene description for Sdhb
Gene name succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene symbol Sdhb
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Sdhb
ExoCarta ExoCarta_298596
Entrez Gene 298596
UniProt P21913  
 Sdhb identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Sdhb
Molecular Function
    3 iron, 4 sulfur cluster binding GO:0051538 ISS
    succinate dehydrogenase (ubiquinone) activity GO:0008177 IMP
    2 iron, 2 sulfur cluster binding GO:0051537 ISS
    4 iron, 4 sulfur cluster binding GO:0051539 ISS
    ubiquinone binding GO:0048039 ISS
    electron carrier activity GO:0009055 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    respiratory electron transport chain GO:0022904 IMP
    succinate metabolic process GO:0006105 IMP
    tricarboxylic acid cycle GO:0006099 IEA
Subcellular Localization
    mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 ISS
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 ISS
    extracellular exosome GO:0070062 ISO
    respiratory chain complex II GO:0045273 ISO
 Experiment description of studies that identified Sdhb in exosomes
1
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sdhb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sdhb is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) IEA Reactome
Respiratory electron transport IEA Reactome





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