ExoCarta: Gene summary

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Gene description for Rer1
Gene name	retention in endoplasmic reticulum sorting receptor 1
Gene symbol	Rer1
Other names/aliases	RGD1306324
Species	Rattus norvegicus
Database cross references - Rer1
ExoCarta	ExoCarta_298675
Entrez Gene	298675
UniProt	Q498C8
Rer1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Rer1

Molecular Function
	acetylcholine receptor binding	GO:0033130	ISO
Biological Process
	skeletal muscle acetylcholine-gated channel clustering	GO:0071340	ISO
	retrograde vesicle-mediated transport, Golgi to ER	GO:0006890	ISO
	positive regulation of establishment of protein localization to plasma membrane	GO:0090004	ISO
	neuromuscular junction development	GO:0007528	ISO
Subcellular Localization
	Golgi apparatus	GO:0005794	ISO
	cell surface	GO:0009986	ISO
	integral component of Golgi membrane	GO:0030173	ISO
	endoplasmic reticulum-Golgi intermediate compartment	GO:0005793	ISO

Experiment description of studies that identified Rer1 in exosomes

Experiment ID

ISEV standards
✔ EM	EV Biophysical techniques
✔ TSG101\|HSP90\|HSC70	EV Cytosolic markers
✔ MHCI	EV Membrane markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D4 Rep 1

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.16-1.21 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting