Gene description for Rer1
Gene name retention in endoplasmic reticulum sorting receptor 1
Gene symbol Rer1
Other names/aliases RGD1306324
Species Rattus norvegicus
 Database cross references - Rer1
ExoCarta ExoCarta_298675
Vesiclepedia VP_298675
Entrez Gene 298675
UniProt Q498C8  
 Rer1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Rer1
Molecular Function
    acetylcholine receptor binding GO:0033130 IEA
    acetylcholine receptor binding GO:0033130 ISO
Biological Process
    protein retention in ER lumen GO:0006621 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IEA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 ISO
    neuromuscular junction development GO:0007528 ISO
    skeletal muscle acetylcholine-gated channel clustering GO:0071340 IEA
    skeletal muscle acetylcholine-gated channel clustering GO:0071340 ISO
    positive regulation of protein localization to plasma membrane GO:1903078 IEA
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IEA
    Golgi membrane GO:0000139 ISO
    cytoplasm GO:0005737 IEA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
 Experiment description of studies that identified Rer1 in sEVs
1
Experiment ID 94
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rer1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rer1 is involved
No pathways found





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