Gene description for Mycn
Gene name v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Gene symbol Mycn
Other names/aliases N-myc
Nmuc1
Nmyc
Species Rattus norvegicus
 Database cross references - Mycn
ExoCarta ExoCarta_298894
Entrez Gene 298894
UniProt Q63379  
 Mycn identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Mycn
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    DNA binding GO:0003677 IEA
    protein dimerization activity GO:0046983 IEA
Biological Process
    embryonic skeletal system morphogenesis GO:0048704 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of mesenchymal cell proliferation GO:0002053 ISO
    embryonic digit morphogenesis GO:0042733 ISO
    positive regulation of cell death GO:0010942 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    lung development GO:0030324 ISO
    cartilage condensation GO:0001502 ISO
    negative regulation of astrocyte differentiation GO:0048712 ISO
    negative regulation of reactive oxygen species metabolic process GO:2000378 ISO
    branching morphogenesis of an epithelial tube GO:0048754 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Mycn in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Mycn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mycn is involved
No pathways found





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