Gene description for Mycn
Gene name v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Gene symbol Mycn
Other names/aliases N-myc
Nmuc1
Nmyc
Species Rattus norvegicus
 Database cross references - Mycn
ExoCarta ExoCarta_298894
Vesiclepedia VP_298894
Entrez Gene 298894
UniProt Q63379  
 Mycn identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Mycn
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA binding GO:0003677 IEA
    DNA-binding transcription factor activity GO:0003700 IEA
    kinase binding GO:0019900 IEA
    kinase binding GO:0019900 ISO
    protein dimerization activity GO:0046983 IEA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    cartilage condensation GO:0001502 IEA
    cartilage condensation GO:0001502 ISO
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    positive regulation of mesenchymal cell proliferation GO:0002053 ISO
    regulation of DNA-templated transcription GO:0006355 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    cell population proliferation GO:0008283 ISO
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of gene expression GO:0010629 ISO
    lung development GO:0030324 IEA
    lung development GO:0030324 ISO
    embryonic digit morphogenesis GO:0042733 IEA
    embryonic digit morphogenesis GO:0042733 ISO
    positive regulation of programmed cell death GO:0043068 IEA
    positive regulation of programmed cell death GO:0043068 ISO
    regulation of inner ear auditory receptor cell differentiation GO:0045607 IEA
    regulation of inner ear auditory receptor cell differentiation GO:0045607 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    embryonic skeletal system morphogenesis GO:0048704 IEA
    embryonic skeletal system morphogenesis GO:0048704 ISO
    astrocyte differentiation GO:0048708 IEA
    astrocyte differentiation GO:0048708 ISO
    negative regulation of astrocyte differentiation GO:0048712 IEA
    negative regulation of astrocyte differentiation GO:0048712 ISO
    branching morphogenesis of an epithelial tube GO:0048754 IEA
    branching morphogenesis of an epithelial tube GO:0048754 ISO
    epithelial cell proliferation GO:0050673 IEA
    epithelial cell proliferation GO:0050673 ISO
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    positive regulation of epithelial cell proliferation GO:0050679 ISO
    autosome genomic imprinting GO:0141068 IEA
    autosome genomic imprinting GO:0141068 ISO
    negative regulation of reactive oxygen species metabolic process GO:2000378 IEA
    negative regulation of reactive oxygen species metabolic process GO:2000378 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Mycn in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Mycn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mycn is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here