Gene description for Lrp1
Gene name	low density lipoprotein receptor-related protein 1
Gene symbol	Lrp1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Lrp1
ExoCarta	ExoCarta_299858
Vesiclepedia	VP_299858
Entrez Gene	299858
Lrp1 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041

Gene ontology annotations for Lrp1

Molecular Function     protease binding GO:0002020 IPI     signaling receptor binding GO:0005102 ISO     calcium ion binding GO:0005509 IEA     calcium ion binding GO:0005509 ISO     protein binding GO:0005515 IPI     coreceptor activity GO:0015026 IDA     alpha-2 macroglobulin receptor activity GO:0016964 IEA     alpha-2 macroglobulin receptor activity GO:0016964 ISO     clathrin heavy chain binding GO:0032050 IEA     clathrin heavy chain binding GO:0032050 ISO     apolipoprotein binding GO:0034185 IBA     apolipoprotein binding GO:0034185 IEA     apolipoprotein binding GO:0034185 ISO     cargo receptor activity GO:0038024 IBA     cargo receptor activity GO:0038024 ISO     protein-containing complex binding GO:0044877 IEA     protein-containing complex binding GO:0044877 ISO     protein serine/threonine kinase binding GO:0120283 IPI Biological Process     astrocyte activation involved in immune response GO:0002265 ISO     cardiac septum development GO:0003279 ISO     receptor-mediated endocytosis GO:0006898 IBA     receptor-mediated endocytosis GO:0006898 IEA     receptor-mediated endocytosis GO:0006898 IMP     receptor-mediated endocytosis GO:0006898 ISO     receptor-mediated endocytosis GO:0006898 ISO     phagocytosis GO:0006909 IBA     phagocytosis GO:0006909 IEA     phagocytosis GO:0006909 ISO     lysosomal transport GO:0007041 ISO     enzyme-linked receptor protein signaling pathway GO:0007167 ISO     positive regulation of cytosolic calcium ion concentration GO:0007204 IMP     cholesterol metabolic process GO:0008203 ISO     negative regulation of gene expression GO:0010629 ISO     negative regulation of cell-substrate adhesion GO:0010812 IMP     positive regulation of cholesterol efflux GO:0010875 ISO     negative regulation of endopeptidase activity GO:0010951 IC     positive regulation of neuron projection development GO:0010976 IMP     negative regulation of neuron projection development GO:0010977 IMP     negative regulation of smooth muscle cell migration GO:0014912 ISO     cerebral cortex development GO:0021987 IEP     negative regulation of Wnt signaling pathway GO:0030178 ISO     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO     receptor internalization GO:0031623 ISO     positive regulation of lipid transport GO:0032370 ISO     regulation of cholesterol transport GO:0032374 ISO     positive regulation of cholesterol transport GO:0032376 ISO     regulation of phospholipase A2 activity GO:0032429 ISO     regulation of actin cytoskeleton organization GO:0032956 ISO     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP     aorta morphogenesis GO:0035909 ISO     negative regulation of apoptotic process GO:0043066 IMP     apoptotic cell clearance GO:0043277 ISO     negative regulation of neuron apoptotic process GO:0043524 IDA     negative regulation of neuron apoptotic process GO:0043524 IMP     positive regulation of axon extension GO:0045773 IMP     positive regulation of endocytosis GO:0045807 IEA     positive regulation of endocytosis GO:0045807 ISO     positive regulation of axon extension involved in regeneration GO:0048691 IDA     positive regulation of collateral sprouting of injured axon GO:0048694 IDA     positive regulation of phagocytosis GO:0050766 IMP     positive regulation of protein transport GO:0051222 IMP     negative regulation of cytosolic calcium ion concentration GO:0051481 IMP     negative regulation of focal adhesion assembly GO:0051895 IMP     negative regulation of SMAD protein signal transduction GO:0060392 ISO     coronary vasculature development GO:0060976 ISO     chemoattraction of axon GO:0061642 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     amyloid-beta clearance GO:0097242 ISO     regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 ISO     amyloid-beta clearance by transcytosis GO:0150093 IBA     amyloid-beta clearance by transcytosis GO:0150093 IEA     amyloid-beta clearance by transcytosis GO:0150093 ISO     amyloid-beta clearance by cellular catabolic process GO:0150094 IBA     amyloid-beta clearance by cellular catabolic process GO:0150094 IEA     amyloid-beta clearance by cellular catabolic process GO:0150094 ISO     transport across blood-brain barrier GO:0150104 ISO     positive regulation of Schwann cell migration GO:1900149 IMP     positive regulation of amyloid-beta clearance GO:1900223 ISO     positive regulation of protein localization to plasma membrane GO:1903078 IEA     positive regulation of protein localization to plasma membrane GO:1903078 ISO     positive regulation of cholesterol import GO:1904109 IMP     positive regulation of transcytosis GO:1904300 ISO     cellular response to amyloid-beta GO:1904646 ISO     positive regulation of vascular associated smooth muscle cell migration GO:1904754 IMP     regulation of pulmonary blood vessel remodeling GO:1905109 ISO     positive regulation of lysosomal protein catabolic process GO:1905167 IEA     positive regulation of lysosomal protein catabolic process GO:1905167 ISO     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 IMP     negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 ISO Subcellular Localization     nucleus GO:0005634 IEA     endosome GO:0005768 IDA     early endosome GO:0005769 IEA     early endosome GO:0005769 ISO     early endosome GO:0005769 NAS     Golgi apparatus GO:0005794 IEA     microtubule organizing center GO:0005815 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 NAS     clathrin-coated pit GO:0005905 IEA     external side of plasma membrane GO:0009897 ISO     membrane GO:0016020 ISO     basolateral plasma membrane GO:0016323 IEA     basolateral plasma membrane GO:0016323 ISO     clathrin-coated vesicle GO:0030136 IDA     dendrite GO:0030425 IDA     insulin-responsive compartment GO:0032593 IDA     neuronal cell body GO:0043025 IDA     receptor complex GO:0043235 IEA     receptor complex GO:0043235 ISO     axonal growth cone GO:0044295 IDA     apical part of cell GO:0045177 IDA     low-density lipoprotein receptor complex GO:0062136 NAS     postsynaptic density membrane GO:0098839 ISO     glutamatergic synapse GO:0098978 ISO