Gene description for Lrp1
Gene name low density lipoprotein receptor-related protein 1
Gene symbol Lrp1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lrp1
ExoCarta ExoCarta_299858
Entrez Gene 299858
 Lrp1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lrp1
Molecular Function
    protein complex binding GO:0032403 ISO
    protein binding GO:0005515 IPI
    protease binding GO:0002020 IPI
    poly(A) RNA binding GO:0044822 ISO
    calcium ion binding GO:0005509 ISO
    apolipoprotein binding GO:0034185 ISO
Biological Process
    cholesterol metabolic process GO:0008203 ISO
    lipoprotein metabolic process GO:0042157 IEP
    positive regulation of protein transport GO:0051222 IMP
    cell proliferation GO:0008283 IMP
    aorta morphogenesis GO:0035909 ISO
    regulation of cholesterol transport GO:0032374 ISO
    positive regulation of cholesterol efflux GO:0010875 ISO
    negative regulation of neuron projection development GO:0010977 IMP
    aging GO:0007568 IEP
    receptor-mediated endocytosis GO:0006898 ISO
    negative regulation of Wnt signaling pathway GO:0030178 ISO
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 ISO
    negative regulation of neuron apoptotic process GO:0043524 IMP
    negative regulation of smooth muscle cell migration GO:0014912 ISO
    protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 IMP
    regulation of actin cytoskeleton organization GO:0032956 ISO
    regulation of phospholipase A2 activity GO:0032429 ISO
    apoptotic cell clearance GO:0043277 ISO
    positive regulation of lipid transport GO:0032370 ISO
    beta-amyloid clearance GO:0097242 ISO
Subcellular Localization
    endosome GO:0005768 IDA
    cytoplasm GO:0005737 ISO
    lysosomal membrane GO:0005765 ISO
    receptor complex GO:0043235 ISO
    membrane GO:0016020 ISO
    dendrite GO:0030425 IDA
    focal adhesion GO:0005925 ISO
    integral component of plasma membrane GO:0005887 ISO
    neuronal cell body GO:0043025 IDA
    clathrin-coated vesicle GO:0030136 IDA
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Lrp1 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lrp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lrp1 is involved
No pathways found





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