ExoCarta: Gene summary

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Gene description for Exosc4
Gene name	exosome component 4
Gene symbol	Exosc4
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Exosc4
ExoCarta	ExoCarta_300045
Vesiclepedia	VP_300045
Entrez Gene	300045
Exosc4 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Exosc4

Molecular Function
	RNA binding	GO:0003723	IBA
	RNA exonuclease activity	GO:0004532	ISO
	mRNA 3'-UTR AU-rich region binding	GO:0035925	ISO
Biological Process
	maturation of 5.8S rRNA	GO:0000460	ISO
	nuclear-transcribed mRNA catabolic process	GO:0000956	ISO
	RNA processing	GO:0006396	ISO
	RNA catabolic process	GO:0006401	ISO
	rRNA catabolic process	GO:0016075	IBA
	positive regulation of cell growth	GO:0030307	ISO
	U4 snRNA 3'-end processing	GO:0034475	IBA
	DNA deamination	GO:0045006	ISO
	defense response to virus	GO:0051607	ISO
	nuclear mRNA surveillance	GO:0071028	IBA
	nuclear mRNA surveillance	GO:0071028	ISO
	histone mRNA catabolic process	GO:0071044	ISO
	poly(A)-dependent snoRNA 3'-end processing	GO:0071051	IBA
Subcellular Localization
	nuclear exosome (RNase complex)	GO:0000176	IBA
	cytoplasmic exosome (RNase complex)	GO:0000177	IBA
	exosome (RNase complex)	GO:0000178	ISO
	euchromatin	GO:0000791	ISO
	nucleus	GO:0005634	ISO
	nucleoplasm	GO:0005654	IEA
	nucleoplasm	GO:0005654	ISO
	nucleolus	GO:0005730	IBA
	nucleolus	GO:0005730	ISO
	cytoplasm	GO:0005737	ISO
	cytosol	GO:0005829	ISO
	intracellular membrane-bounded organelle	GO:0043231	ISO

Experiment description of studies that identified Exosc4 in sEVs

Experiment ID

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|HSP90\|HSC70\|MHCI	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

"Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D2 Rep 2

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.16-1.21 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting