Gene description for Dapk2
Gene name death-associated protein kinase 2
Gene symbol Dapk2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Dapk2
ExoCarta ExoCarta_300799
Vesiclepedia VP_300799
Entrez Gene 300799
 Dapk2 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Dapk2
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    calmodulin binding GO:0005516 ISO
    ATP binding GO:0005524 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    protein phosphorylation GO:0006468 ISO
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 ISO
    positive regulation of apoptotic process GO:0043065 IBA
    anoikis GO:0043276 ISO
    positive regulation of neutrophil chemotaxis GO:0090023 ISO
    neutrophil migration GO:1990266 ISO
    positive regulation of eosinophil chemotaxis GO:2000424 ISO
    regulation of intrinsic apoptotic signaling pathway GO:2001242 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Dapk2 in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Dapk2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dapk2 is involved
No pathways found





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