Gene description for Acy1
Gene name aminoacylase 1
Gene symbol Acy1
Other names/aliases Acy1a
Acy1b
Species Rattus norvegicus
 Database cross references - Acy1
ExoCarta ExoCarta_300981
Entrez Gene 300981
UniProt Q6AYS7  
 Acy1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Acy1
Molecular Function
    metallopeptidase activity GO:0008237 IEA
    aminoacylase activity GO:0004046 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    cellular amino acid metabolic process GO:0006520 IEA
    proteolysis GO:0006508 IEA
    protein catabolic process GO:0030163 TAS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified Acy1 in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Acy1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acy1 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification IEA Reactome





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