Gene description for Acy1
Gene name aminoacylase 1
Gene symbol Acy1
Other names/aliases Acy1a
Acy1b
Species Rattus norvegicus
 Database cross references - Acy1
ExoCarta ExoCarta_300981
Vesiclepedia VP_300981
Entrez Gene 300981
UniProt Q6AYS7  
 Acy1 identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Acy1
Molecular Function
    aminoacylase activity GO:0004046 IBA
    aminoacylase activity GO:0004046 IDA
    aminoacylase activity GO:0004046 IEA
    aminoacylase activity GO:0004046 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    amino acid metabolic process GO:0006520 IEA
    protein catabolic process GO:0030163 TAS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Acy1 in sEVs
1
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Acy1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTNR1B  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Acy1 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification IEA Reactome
Biological oxidations IEA Reactome
Drug ADME IEA Reactome
Metabolism IEA Reactome
Paracetamol ADME IEA Reactome





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