Gene description for Ugt1a8
Gene name UDP glycosyltransferase 1 family, polypeptide A8
Gene symbol Ugt1a8
Other names/aliases UDPGT 1-8
Ugt1
Ugt1a9
Species Rattus norvegicus
 Database cross references - Ugt1a8
ExoCarta ExoCarta_301595
Entrez Gene 301595
 Ugt1a8 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Ugt1a8
Molecular Function
    steroid binding GO:0005496 ISO
    protein heterodimerization activity GO:0046982 ISO
    enzyme inhibitor activity GO:0004857 ISO
    enzyme binding GO:0019899 ISO
    glucuronosyltransferase activity GO:0015020 TAS
    protein homodimerization activity GO:0042803 ISO
    retinoic acid binding GO:0001972 ISO
Biological Process
    negative regulation of cellular glucuronidation GO:2001030 ISO
    negative regulation of catalytic activity GO:0043086 ISO
    flavonoid biosynthetic process GO:0009813 IBA
    cellular response to organic cyclic compound GO:0071407 IEP
    protein glucuronidation GO:0018411 TAS
    coumarin catabolic process GO:0046226 IDA
    flavone metabolic process GO:0051552 ISO
    cellular response to hormone stimulus GO:0032870 IBA
    cellular glucuronidation GO:0052695 ISO
    flavonoid glucuronidation GO:0052696 ISO
    xenobiotic glucuronidation GO:0052697 ISO
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    membrane GO:0016020 IDA
    integral component of plasma membrane GO:0005887 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum chaperone complex GO:0034663 ISO
    intracellular membrane-bounded organelle GO:0043231 IBA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Ugt1a8 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Ugt1a8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ugt1a8 is involved
No pathways found





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