Gene description for Irgm
Gene name immunity-related GTPase family, M
Gene symbol Irgm
Other names/aliases Ifggd3
Ifi1
Species Rattus norvegicus
 Database cross references - Irgm
ExoCarta ExoCarta_303090
Entrez Gene 303090
UniProt Q6AYC2  
 Irgm identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Irgm
Molecular Function
    GTP binding GO:0005525 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    autophagy GO:0006914 IEA
    defense response GO:0006952 ISO
    innate immune response GO:0045087 IEA
Subcellular Localization
    lysosome GO:0005764 ISO
    Golgi membrane GO:0000139 IEA
    phagocytic vesicle membrane GO:0030670 IEA
    autophagosome membrane GO:0000421 IEA
    phagocytic cup GO:0001891 IEA
    late endosome GO:0005770 ISO
    cell projection GO:0042995 IEA
 Experiment description of studies that identified Irgm in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Irgm
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Irgm is involved
No pathways found





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