Gene description for Trim58
Gene name tripartite motif-containing 58
Gene symbol Trim58
Other names/aliases RGD1566174
Species Rattus norvegicus
 Database cross references - Trim58
ExoCarta ExoCarta_303167
Vesiclepedia VP_303167
Entrez Gene 303167
 Trim58 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Trim58
Molecular Function
    zinc ion binding GO:0008270 IEA
    dynein heavy chain binding GO:0045504 ISO
    dynein intermediate chain binding GO:0045505 ISO
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISO
Biological Process
    protein polyubiquitination GO:0000209 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    regulation of gene expression GO:0010468 IBA
    innate immune response GO:0045087 IBA
    protein autoubiquitination GO:0051865 ISO
    positive regulation of erythrocyte enucleation GO:0061931 ISO
    regulation of nuclear migration along microtubule GO:1902838 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Trim58 in sEVs
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Trim58
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trim58 is involved
No pathways found





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