Gene description for Gna13
Gene name guanine nucleotide binding protein (G protein), alpha 13
Gene symbol Gna13
Other names/aliases Galpha13
Species Rattus norvegicus
 Database cross references - Gna13
ExoCarta ExoCarta_303634
Vesiclepedia VP_303634
Entrez Gene 303634
UniProt Q6Q7Y5  
 Gna13 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Gna13
Molecular Function
    G protein-coupled receptor binding GO:0001664 IEA
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    G protein activity GO:0003925 ISO
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
    G-protein beta/gamma-subunit complex binding GO:0031683 IBA
    G-protein beta/gamma-subunit complex binding GO:0031683 IEA
    D5 dopamine receptor binding GO:0031752 IBA
    D5 dopamine receptor binding GO:0031752 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    angiogenesis GO:0001525 ISO
    branching involved in blood vessel morphogenesis GO:0001569 ISO
    in utero embryonic development GO:0001701 ISO
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IMP
    G protein-coupled receptor signaling pathway GO:0007186 IMP
    G protein-coupled receptor signaling pathway GO:0007186 ISO
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 ISO
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 ISS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 IMP
    Rho protein signal transduction GO:0007266 IBA
    Rho protein signal transduction GO:0007266 IEA
    Rho protein signal transduction GO:0007266 ISO
    regulation of blood pressure GO:0008217 ISO
    regulation of cell shape GO:0008360 ISO
    regulation of fibroblast migration GO:0010762 ISO
    cell differentiation GO:0030154 ISO
    platelet activation GO:0030168 ISO
    activation of phospholipase D activity GO:0031584 IMP
    intracellular signal transduction GO:0035556 ISO
    regulation of postsynapse assembly GO:0150052 ISO
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IMP
    negative regulation of vascular associated smooth muscle cell migration GO:1904753 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    heterotrimeric G-protein complex GO:0005834 IBA
    brush border membrane GO:0031526 IBA
    brush border membrane GO:0031526 IDA
    melanosome GO:0042470 IEA
    postsynapse GO:0098794 ISO
 Experiment description of studies that identified Gna13 in sEVs
1
Experiment ID 99
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Gna13
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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