ExoCarta: Gene summary

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Gene description for Serpinc1
Gene name	serpin peptidase inhibitor, clade C (antithrombin), member 1
Gene symbol	Serpinc1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Serpinc1
ExoCarta	ExoCarta_304917
Entrez Gene	304917
Serpinc1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Serpinc1

Molecular Function
	protease binding	GO:0002020	ISO
	heparin binding	GO:0008201	IEA
	protein binding	GO:0005515	IPI
	serine-type endopeptidase inhibitor activity	GO:0004867	IEA
Biological Process
	regulation of blood coagulation, intrinsic pathway	GO:2000266	IEA
	negative regulation of inflammatory response	GO:0050728	IMP
	negative regulation of endopeptidase activity	GO:0010951	IEA
	response to nutrient	GO:0007584	IDA
Subcellular Localization
	extracellular space	GO:0005615	ISO
	extracellular exosome	GO:0070062	ISO
	blood microparticle	GO:0072562	ISO

Experiment description of studies that identified Serpinc1 in exosomes

Experiment ID

ISEV standards
✔ EM	EV Biophysical techniques
✔ TSG101\|HSP90\|HSC70	EV Cytosolic markers
✔ MHCI	EV Membrane markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D7 Rep 1

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.25 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting