Gene description for Hsd17b13
Gene name hydroxysteroid (17-beta) dehydrogenase 13
Gene symbol Hsd17b13
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Hsd17b13
ExoCarta ExoCarta_305150
Vesiclepedia VP_305150
Entrez Gene 305150
UniProt Q5M875  
 Hsd17b13 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Hsd17b13
Molecular Function
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IEA
    all-trans-retinol dehydrogenase (NAD+) activity GO:0004745 IEA
    steroid dehydrogenase activity GO:0016229 IBA
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IBA
Biological Process
    lipid metabolic process GO:0006629 IEA
    positive regulation of lipid biosynthetic process GO:0046889 IEA
    positive regulation of lipid biosynthetic process GO:0046889 ISO
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    lipid droplet GO:0005811 IBA
    lipid droplet GO:0005811 IEA
    lipid droplet GO:0005811 ISO
    lipid droplet GO:0005811 ISS
 Experiment description of studies that identified Hsd17b13 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Hsd17b13
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hsd17b13 is involved
PathwayEvidenceSource
Lipid particle organization IEA Reactome
Metabolism IEA Reactome
Metabolism of lipids IEA Reactome





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