Gene description for Drg1
Gene name developmentally regulated GTP binding protein 1
Gene symbol Drg1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Drg1
ExoCarta ExoCarta_305470
Vesiclepedia VP_305470
Entrez Gene 305470
 Drg1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Drg1
Molecular Function
    GTPase activity GO:0003924 ISO
    GTP binding GO:0005525 IBA
    microtubule binding GO:0008017 ISO
    potassium ion binding GO:0030955 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    cytoplasmic translation GO:0002181 IBA
    positive regulation of microtubule polymerization GO:0031116 ISO
    regulation of mitotic spindle assembly GO:1901673 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
 Experiment description of studies that identified Drg1 in sEVs
1
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Drg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Drg1 is involved
No pathways found





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