Gene description for Sptbn1
Gene name spectrin, beta, non-erythrocytic 1
Gene symbol Sptbn1
Other names/aliases Spnb1
Spnb2
Species Rattus norvegicus
 Database cross references - Sptbn1
ExoCarta ExoCarta_305614
Entrez Gene 305614
 Sptbn1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Sptbn1
Molecular Function
    ankyrin binding GO:0030506 ISO
    phospholipid binding GO:0005543 IEA
    protein complex binding GO:0032403 IPI
    actin binding GO:0003779 IEA
    GTPase binding GO:0051020 ISO
    structural constituent of cytoskeleton GO:0005200 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    SMAD protein import into nucleus GO:0007184 ISO
    membrane assembly GO:0071709 ISO
    mitotic cytokinesis GO:0000281 ISO
    plasma membrane organization GO:0007009 ISO
    Golgi to plasma membrane protein transport GO:0043001 ISO
    regulation of protein localization to plasma membrane GO:1903076 ISO
    positive regulation of interleukin-2 secretion GO:1900042 ISO
    common-partner SMAD protein phosphorylation GO:0007182 ISO
    protein targeting to plasma membrane GO:0072661 ISO
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
Subcellular Localization
    cortical cytoskeleton GO:0030863 ISO
    spectrin GO:0008091 IEA
    intracellular GO:0005622 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    protein complex GO:0043234 IDA
    neuronal postsynaptic density GO:0097481 ISO
    cuticular plate GO:0032437 ISO
    M band GO:0031430 ISO
    axolemma GO:0030673 ISO
    nucleolus GO:0005730 ISO
    cell GO:0005623 ISO
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Sptbn1 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Sptbn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sptbn1 is involved
No pathways found





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