Gene description for Lcp1
Gene name lymphocyte cytosolic protein 1
Gene symbol Lcp1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lcp1
ExoCarta ExoCarta_306071
Entrez Gene 306071
 Lcp1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Lcp1
Molecular Function
    calcium ion binding GO:0005509 IEA
    GTPase binding GO:0051020 ISO
    actin filament binding GO:0051015 ISO
    identical protein binding GO:0042802 ISO
    molecular_function GO:0003674 ND
Biological Process
    positive regulation of podosome assembly GO:0071803 ISO
    organ regeneration GO:0031100 IEP
    actin filament bundle assembly GO:0051017 ISO
    protein kinase A signaling GO:0010737 ISO
    T cell activation involved in immune response GO:0002286 ISO
    wound healing, spreading of cells GO:0044319 ISO
    cell migration GO:0016477 ISO
    regulation of intracellular protein transport GO:0033157 ISO
    extracellular matrix disassembly GO:0022617 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    actin cytoskeleton GO:0015629 ISO
    cytosol GO:0005829 ISO
    filopodium GO:0030175 ISO
    actin filament bundle GO:0032432 ISO
    extracellular space GO:0005615 ISO
    stress fiber GO:0001725 ISO
    ruffle GO:0001726 ISO
    plasma membrane GO:0005886 ISO
    cellular_component GO:0005575 ND
    actin filament GO:0005884 ISO
    podosome GO:0002102 ISO
    focal adhesion GO:0005925 ISO
    phagocytic cup GO:0001891 ISO
 Experiment description of studies that identified Lcp1 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Lcp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lcp1 is involved
No pathways found





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