Gene description for Slc25a15
Gene name solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
Gene symbol Slc25a15
Other names/aliases Ab1-114
Ornt1
Species Rattus norvegicus
 Database cross references - Slc25a15
ExoCarta ExoCarta_306574
Vesiclepedia VP_306574
Entrez Gene 306574
 Slc25a15 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Slc25a15
Molecular Function
    L-ornithine transmembrane transporter activity GO:0000064 IBA
    L-ornithine transmembrane transporter activity GO:0000064 IDA
    L-ornithine transmembrane transporter activity GO:0000064 ISO
    L-lysine transmembrane transporter activity GO:0015189 ISO
    L-lysine transmembrane transporter activity GO:0015189 ISS
    antiporter activity GO:0015297 IDA
    antiporter activity GO:0015297 ISO
    L-arginine transmembrane transporter activity GO:0061459 ISO
    L-arginine transmembrane transporter activity GO:0061459 ISS
Biological Process
    biological_process GO:0008150 ND
    L-lysine transmembrane transport GO:1903401 ISO
    L-lysine transmembrane transport GO:1903401 ISS
    L-arginine transmembrane transport GO:1903826 ISO
    L-arginine transmembrane transport GO:1903826 ISS
    mitochondrial L-ornithine transmembrane transport GO:1990575 IBA
Subcellular Localization
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    mitochondrion GO:0005739 ISS
    mitochondrial inner membrane GO:0005743 IEA
 Experiment description of studies that identified Slc25a15 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Slc25a15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc25a15 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Urea cycle IEA Reactome





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