Gene description for Adamts8
Gene name a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
Gene symbol Adamts8
Other names/aliases METH-2
METH2
Species Mus musculus
 Database cross references - Adamts8
ExoCarta ExoCarta_30806
Entrez Gene 30806
UniProt P57110  
 Adamts8 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Adamts8
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    zinc ion binding GO:0008270 IEA
    metal ion binding GO:0046872 IEA
    peptidase activity GO:0008233 IEA
    hydrolase activity GO:0016787 IEA
    heparin binding GO:0008201 IEA
    metallopeptidase activity GO:0008237 IEA
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 IEA
 Experiment description of studies that identified Adamts8 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Adamts8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adamts8 is involved
No pathways found





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