Gene description for Tomm40
Gene name translocase of outer mitochondrial membrane 40 homolog (yeast)
Gene symbol Tomm40
Other names/aliases OM38
TOM40
Species Rattus norvegicus
 Database cross references - Tomm40
ExoCarta ExoCarta_308416
Entrez Gene 308416
UniProt Q75Q40  
 Tomm40 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Tomm40
Molecular Function
    porin activity GO:0015288 IEA
    protein transmembrane transporter activity GO:0008320 IMP
Biological Process
    protein transmembrane transport GO:0071806 IMP
    protein transport GO:0015031 TAS
    protein targeting to mitochondrion GO:0006626 ISO
    transmembrane transport GO:0055085 IEA
    ion transport GO:0006811 IEA
Subcellular Localization
    pore complex GO:0046930 IEA
    nucleoplasm GO:0005654 ISO
    integral component of mitochondrial outer membrane GO:0031307 IDA
    mitochondrial outer membrane translocase complex GO:0005742 ISO
    integral component of membrane GO:0016021 ISO
    integral component of mitochondrial membrane GO:0032592 ISO
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrion GO:0005739 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Tomm40 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Tomm40
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tomm40 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here