Gene description for Tomm40
Gene name translocase of outer mitochondrial membrane 40 homolog (yeast)
Gene symbol Tomm40
Other names/aliases OM38
TOM40
Species Rattus norvegicus
 Database cross references - Tomm40
ExoCarta ExoCarta_308416
Vesiclepedia VP_308416
Entrez Gene 308416
UniProt Q75Q40  
 Tomm40 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Tomm40
Molecular Function
    monoatomic cation channel activity GO:0005261 IDA
    protein binding GO:0005515 IPI
    protein transmembrane transporter activity GO:0008320 IBA
    protein transmembrane transporter activity GO:0008320 IEA
    protein transmembrane transporter activity GO:0008320 IMP
    porin activity GO:0015288 IEA
    preprotein binding GO:0070678 IDA
Biological Process
    protein targeting to mitochondrion GO:0006626 IDA
    protein targeting to mitochondrion GO:0006626 IMP
    protein targeting to mitochondrion GO:0006626 ISO
    protein import into mitochondrial matrix GO:0030150 IBA
    protein import into mitochondrial matrix GO:0030150 IEA
    positive regulation of apoptotic process GO:0043065 IMP
    protein insertion into mitochondrial membrane GO:0051204 IMP
    monoatomic cation transmembrane transport GO:0098655 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial outer membrane GO:0005741 ISO
    mitochondrial outer membrane translocase complex GO:0005742 IBA
    mitochondrial outer membrane translocase complex GO:0005742 IDA
    mitochondrial outer membrane translocase complex GO:0005742 IEA
    mitochondrial outer membrane translocase complex GO:0005742 ISO
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial inner membrane GO:0005743 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    membrane GO:0016020 ISO
    mitochondrial membrane GO:0031966 ISO
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IEA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 ISO
    pore complex GO:0046930 IEA
 Experiment description of studies that identified Tomm40 in sEVs
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Tomm40
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tomm40 is involved
PathwayEvidenceSource
Autophagy IEA Reactome
Macroautophagy IEA Reactome
Mitophagy IEA Reactome
PINK1-PRKN Mediated Mitophagy IEA Reactome
Selective autophagy IEA Reactome





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